Behaviorally functional opioid systems in infant rats: I. Evidence for olfactory and gustatory classical conditioning.
Behaviorally functional opioid systems in infant rats: I. Evidence for olfactory and gustatory classical conditioning.
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幼鼠的行为功能性阿片类药物系统：I.嗅觉和味觉经典调节的证据。
DOI：
10.1037//0735-7044.100.3.359
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发表时间：
1986
影响因子：
1.9
通讯作者：
Blass,EM
中科院分区：
文献类型：
--
作者：
Kehoe,P;Blass,EM
为了研究新生大鼠阿片类药物系统的行为功能，我们进行了两个系列的实验。在一项研究中，研究了外源性阿片类药物对5日龄幼仔的增强作用。具体地说，评估了婴儿将哺乳时接受的糖精的新味道与ip吗啡注射联系起来的能力。在注射吗啡之前接受0.5毫升糖精的大鼠在第10天摄入的糖精比对照组大鼠多得多。第二组实验是为了确定幼鼠是否能将一种新气味与吗啡注射联系在一起。条件作用五天后，与生理盐水对照组相比，接受吗啡治疗的小鼠更喜欢这种刺激。因此，无论是在哺乳时体验到的新的味觉刺激，还是与社交隔离时体验到的气味，都形成了积极的联系。条件反射是线索特异性的，并至少保留5天。这些联系的形成被条件作用前给予的阿片类拮抗剂阻断。这些数据提示了行为功能的阿片受体，并提高了内源性阿片在幼年大鼠的兴奋过程中发挥功能作用的可能性。
In order to characterize behavioral function of opioid systems in neonatal rats, two series of experiments were initiated. In one, the reinforcing properties of exogenous opioids were investigated in 5-day-old pups. Specifically, the infant's ability to associate the novel taste of saccharin, received while suckling, with ip morphine injections was assessed. Rats that received 0.5 ml of saccharin prior to morphine administration ingested considerably more saccharin on Day 10 than did control rats. The second set of experiments was conducted to determine whether rat pups could associate a novel odor with morphine administration. Five days after conditioning, that stimulus was highly preferred by morphine-treated pups compared with saline control pups. Thus positive associations were formed with either a novel taste stimulus experienced while suckling or with an odor experienced during social isolation. Conditioning was cue specific and was retained for at least 5 days. The formation of these associations was blocked with opioid antagonists given prior to conditioning. These data suggest behaviorally functional opioid receptors and raise the possibility of a functional role of the endogenous opioids in motivational processes in infant rats.