Statistical resolution of genetic heterogeneity in familial disease
Statistical resolution of genetic heterogeneity in familial disease
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家族性疾病遗传异质性的统计解析
DOI：
10.1111/j.1469-1809.1976.tb00132.x
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发表时间：
1976
影响因子：
1.9
通讯作者：
Charles Smith
中科院分区：
文献类型：
--
作者：
Charles Smith
如果一种疾病可以根据任何标准（临床、生化、生理或统计）分为两个或更多组，那么可以测试分组以确定是否已识别出该疾病的遗传独立形式。所需的数据只是两个疾病组在每个疾病组先证者亲属中的频率。在家族性疾病的遗传异质性的搜索，提出了这样的不同群体的系统搜索。
If a disease can be split into two or more groups on any criterion (clinical, biochemical, physiological or statistical) then the grouping can be tested to establish if genetically independent forms of the disease have been identified. The data required are simply the frequencies of the two disease groups in relatives of probands for each of the disease groups. A systematic search for such distinct groups is proposed in searches for genetic heterogeneity in familial diseases.