Frequent gains of 20q and losses of 18q are associated with lymph node metastasis in intestinal-type gastric cancer.
Frequent gains of 20q and losses of 18q are associated with lymph node metastasis in intestinal-type gastric cancer.
复制标题
20q的频繁增加和18q的减少与肠型胃癌的淋巴结转移有关。
作者：
S. Hidaka;T. Yasutake;M. Kondo;H. Takeshita;H. Yano;Masatoshi Haseba;T. Tsuji;T. Sawai;T. Nakagoe;Y. Tagawa
背景
BACKGROUND
The genetic aberrations associated with development and progression of gastric carcinomas (GCs) are poorly understood. The aim of this study was to identify chromosomal aberrations associated with the development and/or progression of intestinal-type GC.
MATERIALS AND METHODS
Comparative genomic hybridization (CGH) analysis was applied to 36 intestinal-type GCs. We compared chromosomal aberrations detected by CGH analysis with clinicopathological parameters.
RESULTS
Frequent gains of DNA copy number were found on 8q, 13q, 20q, 3q, 6q and losses were found on 17p, 18q in intestinal-type GCs. No significant differences were observed in the chromosomal aberrations between tumor stage, tumor location, peritoneal dissemination, liver metastasis or other distant metastasis. However, the frequencies of 20q12-13 gain and 18q21-22 loss were significantly higher in tumors with lymph node metastasis than in those without metastasis.
CONCLUSION
Gains of 20q and losses of 18q may contribute to lymph node metastasis and the malignant phenotype in intestinal-type GCs.