Adherence to preexposure prophylaxis: current, emerging, and anticipated bases of evidence.
Adherence to preexposure prophylaxis: current, emerging, and anticipated bases of evidence.
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DOI：
10.1093/cid/ciu266
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Stirratt MJ
中科院分区：
文献类型：
--
作者：
Amico KR;Stirratt MJ
尽管关于人类免疫缺陷病毒（HIV）暴露前预防（PrEP）依从性的讨论和争论相当多，但很少有数据表明开放标签PrEP依从性的特征。目前的证据基础主要是通过大型随机对照试验（RCTs）中主动受试者的药物检测来研究安慰剂对照研究药物的依从性。盲法随机对照试验和开放标签使用背景之间的重要差异表明，从研究产品依从性推广到实际使用PrEP时要谨慎。目前，针对开放标签PrEP依从性的具体证据很少，但随着推广、示范项目和更严格的研究收集和呈现结果，未来几年将迅速扩大。目前建立的证据基础还不能预测开放标签有效PrEP的吸收、依从性或持久性。新出现的证据表明，与安慰剂对照研究相比，一些队列在开放标签使用中可以执行更好的依从性。目前，PrEP在美国的应用进展缓慢；这种情况是否会随着基层和社区努力提高对PrEP作为一种有效的艾滋病毒预防选择的认识而改变，仍有待确定。根据多项PrEP使用指南的建议，目前所有示范项目都提供PrEP教育和/或咨询。PrEP支持方法一般分为基于社区、技术、监测和综合性健康促进方法。开发和实施研究，超越研究产品使用或开放标签PrEP依从性的简单相关性，转向更全面的社会行为和社会生态依从性决定因素模型，将大大加快进展。需要进行干预研究，以确定支持开放标签PrEP依从性的有效模式。
Despite considerable discussion and debate about adherence to preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV), scant data are available that characterize patterns of adherence to open-label PrEP. The current evidence base is instead dominated by research on adherence to placebo-controlled investigational drug by way of drug detection in active-arm participants of large randomized controlled trials (RCTs). Important differences between the context of blinded RCTs and open-label use suggest caution when generalizing from study product adherence to real-world PrEP use. Evidence specific to open-label PrEP adherence is presently sparse but will expand rapidly over the next few years as roll-out, demonstration projects, and more rigorous research collect and present findings. The current evidence bases established cannot yet predict uptake, adherence, or persistence with open-label effective PrEP. Emerging evidence suggests that some cohorts could execute better adherence in open-label use vs placebo-controlled research. Uptake of PrEP is presently slow in the United States; whether this changes as grassroots and community efforts increase awareness of PrEP as an effective HIV prevention option remains to be determined. As recommended by multiple guidelines for PrEP use, all current demonstration projects offer PrEP education and/or counseling. PrEP support approaches generally fall into community-based, technology, monitoring, and integrated sexual health promotion approaches. Developing and implementing research that moves beyond simple correlates of either study product use or open-label PrEP adherence toward more comprehensive models of sociobehavioral and socioecological adherence determinants would greatly accelerate progress. Intervention research is needed to identify effective models of support for open-label PrEP adherence.
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影响因子：
168.9
作者：
Choopanya, Kachit;Martin, Michael;Vanichseni, Suphak
通讯作者：
Vanichseni, Suphak
影响因子：
39.2
作者：
Altice, FL;Friedland, GH
通讯作者：
Friedland, GH
DOI：
10.1126/science.1193748
发表时间：
2010-09-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abdool Karim Q;Abdool Karim SS;Frohlich JA;Grobler AC;Baxter C;Mansoor LE;Kharsany AB;Sibeko S;Mlisana KP;Omar Z;Gengiah TN;Maarschalk S;Arulappan N;Mlotshwa M;Morris L;Taylor D;CAPRISA 004 Trial Group
通讯作者：
CAPRISA 004 Trial Group
DOI：
10.1056/nejmoa1108524
发表时间：
2012-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baeten JM;Donnell D;Ndase P;Mugo NR;Campbell JD;Wangisi J;Tappero JW;Bukusi EA;Cohen CR;Katabira E;Ronald A;Tumwesigye E;Were E;Fife KH;Kiarie J;Farquhar C;John-Stewart G;Kakia A;Odoyo J;Mucunguzi A;Nakku-Joloba E;Twesigye R;Ngure K;Apaka C;Tamooh H;Gabona F;Mujugira A;Panteleeff D;Thomas KK;Kidoguchi L;Krows M;Revall J;Morrison S;Haugen H;Emmanuel-Ogier M;Ondrejcek L;Coombs RW;Frenkel L;Hendrix C;Bumpus NN;Bangsberg D;Haberer JE;Stevens WS;Lingappa JR;Celum C;Partners PrEP Study Team
通讯作者：
Partners PrEP Study Team
影响因子：
4.4
作者：
Amico, K. R.;McMahan, Vanessa;Liu, Albert
通讯作者：
Liu, Albert