An analysis of coupled multicomponent diffusion in interstitial tissue.
An analysis of coupled multicomponent diffusion in interstitial tissue.
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间质组织中耦合多组分扩散的分析。
DOI：
10.1115/1.2895715
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Paynter,HM
中科院分区：
文献类型：
--
作者：
Schreuders,PD;Diller,KR;BeamanJr,JJ;Paynter,HM
建立了一个一维多组分动力学模型，模拟了水、大分子和间隙基质组成的三元体系中大分子的间隙扩散。单个组分的运动被建模为发生在离散的低能量威尔斯井沿着在物种占领方面定义的路径之间的有限跳跃。流速表示为局部物种浓度，跳跃距离和动力学频率参数的函数。该模型，在伪键合图的形式实现，进行了检查，通过拟合它的荧光素标记的葡聚糖的运输获得的数据，以确定该特定系统的动力学常数。
A one-dimensional multicomponent kinetic model was developed to simulate the interstitial diffusion of macromolecules in a three component system, consisting of water, the macromolecule and the interstitial matrix. Movement of the individual components was modeled as occurring in finite jumps between discrete low energy wells along paths defined in terms of species occupation. The flow rate was expressed as a function of the local species concentration, the jump distance, and a kinetic frequency parameter. The model, implemented in pseudo-bond graph form, was examined by fitting it to data obtained for the transport of fluorescein tagged dextran to determine the kinetic constants for that specific system.