MEASUREMENTS OF CALCIUM AND OTHER ELEMENTS IN MUSCLE BIOPSY SAMPLES FROM PATIENTS WITH DUCHENNE MUSCULAR-DYSTROPHY
MEASUREMENTS OF CALCIUM AND OTHER ELEMENTS IN MUSCLE BIOPSY SAMPLES FROM PATIENTS WITH DUCHENNE MUSCULAR-DYSTROPHY
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DOI：
10.1016/0009-8981(85)90202-5
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
EDWARDS, RHT
中科院分区：
文献类型：
--
作者：
JACKSON, MJ;JONES, DA;EDWARDS, RHT
用原子吸收光谱法测定了正常人和各种神经肌肉疾病患者的肌肉组织中钙、镁、钠、钾的含量。Duchenne肌营养不良症患者和其他肌肉疾病患者的肌肉钙含量均显著高于正常对照组和患者对照组。与对照组相比，任何一组的肌肉钠含量都没有显著变化。Duchenne肌营养不良症患者肌肉中的镁和钾水平降低，尽管肌肉的镁/钾比值没有变化，最可能的解释是细胞内成分的非特异性丢失。
The Ca, Mg, Na and K content of needle biopsy samples of human muscle from control subjects and patients with various neuromuscular disorders was analyzed by atomic absorption spectrometry. The Ca content of muscle from both patients with Duchenne muscular dystrophy and other myopathies was significantly elevated compared to both normal and patient control subjects. Muscle Na content was not significantly altered in any group compared to control subjects. Decreased Mg and K levels were found in muscle from patients with Duchenne muscular dystrophy, although the muscle Mg/K ratio was unchanged, the most likely explanation for this being non-specific loss of intracellular components from the cell.