Decoding the function of an oncogenic transcription factor: finding the first responders.
Decoding the function of an oncogenic transcription factor: finding the first responders.
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DOI：
10.1016/j.molcel.2021.01.008
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发表时间：
2021-02
期刊：
影响因子：
16
通讯作者：
Chao Lu
中科院分区：
文献类型：
--
作者：
Chao Lu
转录因子（TF）在人类疾病中经常发生改变。确定TF的直接和直接靶基因对于理解其在病理生理学中的作用至关重要。Stengel等人（2020）应用化学遗传学和新生转录组作图技术来定义由AML 1-ETO（一种常见于急性髓性白血病（AML）的致癌TF融合蛋白）调控的核心基因集。
Transcription factors (TFs) are frequently altered in human diseases. Identifying the direct and immediate target genes of TFs is critical to understanding their role in pathophysiology. Stengel et al. (2020) applied chemogenetic and nascent transcriptome mapping technologies to define the core gene set regulated by AML1-ETO—an oncogenic TF fusion protein frequently found in acute myeloid leukemia (AML).