Effect of Obesity on Retinal Integrity in African Americans and Caucasian Americans With Relapsing Multiple Sclerosis.
Effect of Obesity on Retinal Integrity in African Americans and Caucasian Americans With Relapsing Multiple Sclerosis.
复制标题
DOI：
10.3389/fneur.2021.743592
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Bernitsas E
中科院分区：
文献类型：
--
作者：
Rube J;Bross M;Bernitsas C;Hackett M;Bao F;Bernitsas E
目的：研究肥胖对复发-缓解型多发性硬化症（RRMS）非裔美国人（AAs）和白种人（CAs）视网膜结构的影响。方法：136例无视神经炎病史的RRMS患者根据体重指数（BMI）分为肥胖组67例（40 AA, 27 CA，平均BMI±SD: 36.7±5.8）和非肥胖组69例（23 AA, 46 CA，平均BMI±SD: 24.0±3.1）。通过光学相干断层扫描（OCT）对乳头周围视网膜神经纤维层（pRNFL）的厚度进行量化，并将其分为四象限厚度：上(S)、下(I)、颞(T)和鼻(N)。获取乳头状斑束（PMB）厚度、视网膜神经纤维层（RNFL）、神经节细胞+内丛状层（GCIPL）、内核（INL）、外丛状（OPL）、外核（ONL）、黄斑总体积（TMV）。结果：肥胖与T层厚度降低（58.54±15.2比61.9 12.4,p = 0.044）、INL升高（0.98±0.07比0.96±0.06,p = 0.034）、RNFL降低（0.77±0.14比0.82±0.12,p = 0.009）相关。肥胖AA明显薄T(58.54±15.19和61.91±12.39,p = 0.033), N(68.94±2.7和77.94±3.3,p = 0.044),和烟草花叶病毒(8.15±0.07和8.52±0.09,p = 0.003), RNFL(0.74±0.02和0.82±0.02,p = 0.013), OPL(0.76±0.01和0.79±0.1,p = 0.050),辊筒(1.68±0.031和1.79±0.038,p = 0.026),和GCIPL(1.78±0.04和1.9±0.05,p = 0.038)相比,肥胖CA。non-obesity患者当中,辊筒显著低于AA(1.78±0.04和1.9±0.05,P < 0.001)。结论：肥胖与RRMS患者视网膜结构异常有关。它对AA的影响可能比CA更突出。需要大规模的纵向研究来验证我们的发现。
Objective: To study the effect of obesity on retinal structures in African Americans (AAs) and Caucasian Americans (CAs) with relapsing-remitting multiple sclerosis (RRMS). Methodology: About 136 patients with RRMS without history of optic neuritis were divided into two groups, based on body mass index (BMI): 67 obese (40 AA, 27 CA, mean BMI ± SD: 36.7 ± 5.8), and 69 non-obese (23 AA, 46 CA, mean BMI ± SD: 24.0 ± 3.1). The peripapillary retinal nerve fiber layer (pRNFL) thickness was quantified by optical coherence tomography (OCT) and was segmented into quadrant thickness: superior (S), inferior (I), temporal (T), and nasal (N). Papillomacular bundle (PMB) thickness, retinal nerve fiber layer (RNFL), ganglion cell + inner plexiform layer (GCIPL), inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL), and total macular (TMV) volumes were obtained. Results: Obesity was associated with lower T thickness (58.54 ± 15.2 vs. 61.9 12.4, p = 0.044), higher INL (0.98 ± 0.07 vs. 0.96 ± 0.06, p = 0.034), and lower RNFL (0.77 ± 0.14 vs. 0.82 ± 0.12, p = 0.009) volumes. Obese AA had significantly thinner T (58.54 ± 15.19 vs. 61.91 ± 12.39, p = 0.033), N (68.94 ± 2.7 vs. 77.94 ± 3.3, p = 0.044), and TMV (8.15 ± 0.07 vs. 8.52 ± 0.09, p = 0.003), RNFL (0.74 ± 0.02 vs. 0.82 ± 0.02, p = 0.013), OPL (0.76 ± 0.01 vs. 0.79 ± 0.1, p = 0.050), ONL (1.68 ± 0.031 vs. 1.79 ± 0.038, p = 0.026), and GCIPL (1.78 ± 0.04 vs. 1.9 ± 0.05, p = 0.038) compared to obese CA. Among patients with non-obesity, the ONL was significantly lower in AA (1.78 ± 0.04 vs. 1.9 ± 0.05, p < 0.001). Conclusions: Obesity is associated with retinal structure abnormalities in patients with RRMS. Its impact might be more prominent in AA than CA. Large longitudinal studies are needed to validate our findings.
登录
查看更多内容
影响因子：
5.3
作者：
Marrodan M;Farez MF;Balbuena Aguirre ME;Correale J
通讯作者：
Correale J
影响因子：
11.2
作者：
Saidha S;Al-Louzi O;Ratchford JN;Bhargava P;Oh J;Newsome SD;Prince JL;Pham D;Roy S;van Zijl P;Balcer LJ;Frohman EM;Reich DS;Crainiceanu C;Calabresi PA
通讯作者：
Calabresi PA
影响因子：
4.4
作者：
Graham, Elizabeth C.;You, Yuyi;Klistorner, Alexander
通讯作者：
Klistorner, Alexander
影响因子：
11.2
作者：
Kimbrough, Dorlan J.;Sotirchos, Elias S.;Wilson, James A.;Al-Louzi, Omar;Conger, Amy;Conger, Darrel;Frohman, Teresa C.;Saidha, Shiv;Green, Ari J.;Frohman, Elliot M.;Balcer, Laura J.;Calabresi, Peter A.
通讯作者：
Calabresi, Peter A.
DOI：
10.1097/01.phm.0000078199.99484.e2
发表时间：
2003-08-01
影响因子：
3
作者：
Kaufman, MD;Johnson, SK;Norton, HJ
通讯作者：
Norton, HJ