Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles.
Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles.
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DOI：
10.1101/cshperspect.a025817
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发表时间：
2017-05-01
影响因子：
7.2
通讯作者：
Gelfand VI
中科院分区：
文献类型：
--
作者：
Barlan K;Gelfand VI
微管提供了长的沿着的轨道，广泛的细胞器和囊泡是由驱动蛋白和动力蛋白马达运输。马达蛋白复合物也将货物拴在细胞骨架丝上，帮助促进它们的相互作用和交流。生物化学上不同的微管亚群的产生允许马达的子集识别给定的微管身份，允许细胞质内的进一步组织。运输和拴系都是通过多种模式进行时空调节的，包括通过各种生理信号对机动车-货物和机动车-轨道关联进行急性修改。细胞内运输的严格调节在专门的细胞类型如神经元中特别重要。在这里，我们回顾了控制货物运输的一般机制，并强调了由多种机制监管的运输实例。分子马达沿着细胞骨架轨道移动以递送货物并促进它们在细胞内的相互作用。对货物系留和运输的时空管制有多种形式。
Microtubules provide long tracks along which a broad range of organelles and vesicles are transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to cytoskeletal filaments, helping facilitate their interaction and communication. The generation of biochemically distinct microtubule subpopulations allows subsets of motors to recognize a given microtubule identity, allowing further organization within the cytoplasm. Both transport and tethering are spatiotemporally regulated through multiple modes, including acute modification of both motor–cargo and motor–track associations by various physiological signals. Strict regulation of intracellular transport is particularly important in specialized cell types such as neurons. Here, we review general mechanisms by which cargo transport is controlled and also highlight examples of transport regulated by multiple mechanisms. Molecular motors move along cytoskeletal tracks to deliver cargoes and facilitate their interactions within a cell. The spatiotemporal regulation of cargo tethering and transport takes multiple forms.