Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation
Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation
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DOI：
10.1115/1.2838024
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发表时间：
2008-02-01
影响因子：
1.7
通讯作者：
Yanase, Shinichiro
中科院分区：
文献类型：
--
作者：
Hyakutake, Toru;Tominaga, Shouko;Yanase, Shinichiro
用格子Boltzmann方法对脂质体包裹的血红蛋白(LEH)部分置换红细胞(RBC)后微血管分叉处的流动进行了分析。考虑了母体血管直径为20微米、子体血管直径为20微米的二维对称Y分叉模型，计算了RBC、LEH和氧通量的分布。当只有红细胞以不均匀的流量流入分支时，发生血浆分离，流向较低血流分支的红细胞不成比例地减少。另一方面，当一半的RBC被LEH取代时，RBC流动的偏置增强，而LEH有利地流向低血流分支，因为母血管内的许多LEH悬浮在血浆层中，那里不存在红细胞。因此，分枝的氧通量几乎与流量成正比。这些结果表明，LEH促进了红细胞无法接触到的分支的氧气供应。
Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed using the lattice Boltzmann method. A two-dimensional symmetric Y bifurcation model with a parent vessel diameter of 20 mu m and daughter branch diameters of 20 mu was considered, and the distributions of the RBC, LEH, and oxygen fluxes were calculated. When only RBCs flow into the daughter branches with unevenly distributed flows, plasma separation occurred and the RBC flow to the lower-flow branch was disproportionately decreased. On the other hand, when half of RBC are replaced by LEH, the biasing of RBC flow was enhanced whereas LEH flowed favorably into the lower-flow branch, because many LEH within the parent vessel are suspended in the plasma layer, where no RBCs exist. Consequently, the branched oxygen fluxes became nearly proportional to flows. These results indicate that LEH facilitates oxygen supply to branches that are inaccessible to RBCs.