Fibrogenesis V.: TGF-β signaling pathways
Fibrogenesis V.: TGF-β signaling pathways
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DOI：
10.1152/ajpgi.2000.279.5.g845
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发表时间：
2000-11-01
影响因子：
4.5
通讯作者：
Wells, RG
中科院分区：
文献类型：
--
作者：
Wells, RG
转化生长因子 (TGF)-β 是一种多功能肽生长因子，对生长、分化、细胞外基质沉积和免疫反应具有广泛的潜在影响。在过去的几年里，人们已经详细描述了一般的 TGF-β 信号传导途径，但对决定 TGF-β 反应性质的因素知之甚少。特别是，特异性介导 TGF-β 基质效应的信号通路很少受到关注，尽管它们将成为治疗病理性纤维化的重要治疗靶点。本主题文章重点关注 TGF-β 信号传导，并强调产生基质特异性反应的潜在要点。
Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.