LETS GET SPECIFIC - THE RELATIONSHIP BETWEEN SPECIFICITY AND AFFINITY
LETS GET SPECIFIC - THE RELATIONSHIP BETWEEN SPECIFICITY AND AFFINITY
复制标题
DOI：
10.1016/1074-5521(95)90023-3
复制
发表时间：
1995-10-01
影响因子：
--
通讯作者：
ZICHI, DA
中科院分区：
文献类型：
--
作者：
EATON, BE;GOLD, L;ZICHI, DA
导致高亲和力结合的因素是两个分子的表面在其基态和电荷互补性下的良好配合。完全相同的因素对目标具有高度特异性。我们认为，选择高亲和力结合自动导致高度特异性结合。这一原理可以用来简化筛选方法，目的是产生有用的药物。
The factors that lead to high-affinity binding are a good fit between the surfaces of the two molecules in their ground state and charge complementarity. Exactly the same factors give high specificity for a target. We argue that selection for high-affinity binding automatically leads to highly specific binding. This principle can be used to simplify screening approaches aimed at generating useful drugs.