OCCURRENCE OF SINGLE-STRANDED DNA IN SERUM OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND OTHER DISEASES
OCCURRENCE OF SINGLE-STRANDED DNA IN SERUM OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND OTHER DISEASES
复制标题
DOI：
10.1172/jci107165
复制
发表时间：
1973-01-01
影响因子：
15.9
通讯作者：
KUNKEL, HG
中科院分区：
文献类型：
--
作者：
KOFFLER, D;AGNELLO, V;KUNKEL, HG
单链 DNA (SDNA) 在系统性红斑狼疮 (SLE) 患者的血清中出现率高且浓度最高，观察到的水平高达 250 μg/ml。 SDNA 似乎是抗 SDNA 抗体的免疫原，并在体内形成抗 SDNA-SDNA 和抗 NDNA-SDNA 类型的复合物，这显然在 SLE 患者肾小球肾炎的发病机制中发挥作用，SDNA 在类风湿性关节炎患者血清中的发病率也很高，但水平较低。在其他几种抗 SDNA 抗体发生率较低的疾病中，也发现了较少量的 SDNA。图像
Single-stranded DNA (SDNA) occurs in high incidence and in greatest concentration in the sera of patients with systemic lupus erythematosus (SLE), where levels as high as 250 μg/ml were observed. SDNA appears to be an imunogen for anti-SDNA antibodies and forms complexes in vivo of both anti-SDNA-SDNA and anti-NDNA-SDNA types, which apparently play a role in the pathogenesis of the glomerulonephritis found in patients with SLE, SDNA is also found in high incidence but at lower levels in the sera of patients with rheumatoid arthritis. Lesser amounts of SDNA are found in several other diseases in which a low incidence of anti-SDNA antibodies is observed.Images