Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea.
Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea.
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DOI：
10.1038/emi.2017.40
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发表时间：
2017-06-07
影响因子：
13.2
通讯作者：
MacIntyre CR
中科院分区：
文献类型：
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作者：
Chen X;Chughtai AA;Dyda A;MacIntyre CR
MERS-CoV 感染于 2012 年在沙特阿拉伯王国 (KSA) 出现，并已传播到 26 个国家。然而，80% 的病例发生在沙特阿拉伯。 2015 年，韩国 (SK) 爆发了沙特阿拉伯以外最大规模的疫情。在本报告中，我们对两次疫情进行了流行病学比较。沙特阿拉伯 (2012-2015 年) 1299 例病例和 SK (2015 年) 186 例病例的数据是从公开资源收集的，包括 FluTrackers、世界卫生组织 (WHO) 疫情新闻和沙特卫生部 (MOH)。采用描述性分析、t 检验、卡方检验和二元逻辑回归来比较按国籍划分的病例的人口特征和其他特征（合并症、接触史）。生成了疫情爆发的流行曲线。沙特阿拉伯病例的平均年龄为 51 岁，SK 病例的平均年龄为 54 岁。老年男性（≥70 岁）更有可能被 MERS-CoV 感染或死于 MERS-CoV 感染，并且两国男性的合并症发生率均有所增加。沙特阿拉伯的疫情模式更为复杂，存在动物传人、人传人、医院内和未知暴露等情况，而SK的疫情则更明显是医院内感染。在沙特阿拉伯报告有危险因素的 1186 例 MERS 病例中，有 158 例 (13.3%) 住院，而 SK 则为 175 例 (94.1%)，并且沙特阿拉伯发现暴露风险未知的病例比例有所增加 (710 例，59.9%)。在全球互联的世界中，旅行是新发感染的一个风险因素，所有国家的卫生系统都应针对潜在的中东呼吸综合征冠状病毒输入病例实施更好的分诊系统，以防止大规模流行。
MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012–2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH). Descriptive analysis, t-tests, Chi-square tests and binary logistic regression were conducted to compare demographic and other characteristics (comorbidity, contact history) of cases by nationality. Epidemic curves of the outbreaks were generated. The mean age of cases was 51 years in KSA and 54 years in SK. Older males (⩾70 years) were more likely to be infected or to die from MERS-CoV infection, and males exhibited increased rates of comorbidity in both countries. The epidemic pattern in KSA was more complex, with animal-to-human, human-to-human, nosocomial and unknown exposure, whereas the outbreak in SK was more clearly nosocomial. Of the 1186 MERS cases in KSA with reported risk factors, 158 (13.3%) cases were hospital associated compared with 175 (94.1%) in SK, and an increased proportion of cases with unknown exposure risk was found in KSA (710, 59.9%). In a globally connected world, travel is a risk factor for emerging infections, and health systems in all countries should implement better triage systems for potential imported cases of MERS-CoV to prevent large epidemics.
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影响因子：
11.8
作者：
Kim DW;Kim YJ;Park SH;Yun MR;Yang JS;Kang HJ;Han YW;Lee HS;Kim HM;Kim H;Kim AR;Heo DR;Kim SJ;Jeon JH;Park D;Kim JA;Cheong HM;Nam JG;Kim K;Kim SS
通讯作者：
Kim SS
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56.3
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影响因子：
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作者：
Majumder, Maimuna S.;Kluberg, Sheryl A.;Brownstein, John S.
通讯作者：
Brownstein, John S.
影响因子：
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作者：
MacIntyre, C. Raina
通讯作者：
MacIntyre, C. Raina
影响因子：
3.8
作者：
Gardner, Lauren M.;Rey, David;MacIntyre, C. Raina
通讯作者：
MacIntyre, C. Raina