Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner
Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner
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DOI：
10.1037/0735-7044.118.2.389
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发表时间：
2004-04-01
影响因子：
1.9
通讯作者：
Quirk, GJ
中科院分区：
文献类型：
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作者：
Milad, MR;Vidal-Gonzalez, I;Quirk, GJ
作者最近表明，听觉恐惧条件反射的消退导致内侧前额叶皮层的边缘下（IL）子区域神经元的音调诱发活动增强，这表明IL抑制消退后的恐惧（M。R. Milad，& G. J. Quirk，2002）。为了支持这一发现，配对条件音与短暂（300毫秒）电刺激IL减少条件冻结。目前的研究表明，IL刺激抑制冻结，如果给予0.1秒后的音调开始（音调诱发反应的潜伏期），但没有效果，如果给予1秒前或1秒后的音调开始。这表明，IL门控下游结构的反应，如杏仁核恐惧刺激。
The authors recently showed that extinction of auditory fear conditioning leads to potentiation of tone-evoked activity of neurons in the infralimbic (IL) subregion of the medial prefrontal cortex, suggesting that IL inhibits fear after extinction (M. R. Milad, & G. J. Quirk, 2002). In support of this finding, pairing conditioned tones with brief (300-ms) electrical stimulation of IL reduces conditioned freezing. The present study showed that IL stimulation inhibits freezing if given 0.1 s after tone onset (the latency of tone-evoked responses) but has no effect if given either 1 s before or 1 s after tone onset. This suggests that IL gates the response of downstream structures such as the amygdala to fear stimuli.