Design of aging intervention studies: the NIA interventions testing program
Design of aging intervention studies: the NIA interventions testing program
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DOI：
10.1007/s11357-008-9048-1
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发表时间：
2008-12-01
期刊：
影响因子：
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通讯作者：
Harrison, D. E.
中科院分区：
文献类型：
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作者：
Nadon, N. L.;Strong, R.;Harrison, D. E.
生物老年学领域在理解衰老背后的生物过程方面取得了巨大的进步，并且将这些知识应用于追求衰老干预的时机已经成熟。确定安全、廉价和非侵入性的干预措施，以减缓衰老过程并促进健康老龄化，可能对老年人的生活质量和医疗保健支出产生重大影响。虽然市场上有大量声称能延缓衰老的补充剂和干预措施，但证实这种说法的证据普遍缺乏。在这里，我们描述了由国家老龄化研究所（NIA）资助的老龄化干预测试计划的发展，以测试模型系统中的候选干预措施。该计划的发展突出了长期干预研究的挑战，并提供了应对多地点测试计划严格要求的方法。
The field of biogerontology has made great strides towards understanding the biological processes underlying aging, and the time is ripe to look towards applying this knowledge to the pursuit of aging interventions. Identification of safe, inexpensive, and non-invasive interventions that slow the aging process and promote healthy aging could have a significant impact on quality of life and health care expenditures for the aged. While there is a plethora of supplements and interventions on the market that purport to slow aging, the evidence to validate such claims is generally lacking. Here we describe the development of an aging interventions testing program funded by the National Institute on Aging (NIA) to test candidate interventions in a model system. The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program.