Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats.
Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats.
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DOI：
10.4303/jdar/235967
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发表时间：
2016-05-01
影响因子：
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通讯作者：
Olive, M Foster
中科院分区：
文献类型：
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作者：
Watterson, Lucas R;Kufahl, Peter R;Olive, M Foster
背景：近年来，合成卡西酮3,4-亚甲基二氧基戊酮（MDPV）的滥用急剧增加，通常与其他非法兴奋剂联合使用。目的：我们试图确定反复暴露于MDPV是否会对药物的运动刺激作用产生致敏，以及是否会与甲基苯丙胺（METH）的刺激作用产生交叉致敏。研究设计：雄性Sprague-Dawley大鼠每天1次给予MDPV（1或5 mg/kg）或生理盐水，连续5天，间隔24小时，或每天1次给予MDPV （1 mg/kg）或生理盐水，间隔48小时，连续5天。在交叉致敏实验中，大鼠每天给药一次甲基苯丙胺（1 mg/kg）或MDPV(1或5 mg/kg)，连续5天，间隔48小时，在5天的潜伏期后，分别给急性攻毒注射MDPV （0.5 mg/kg）或甲基苯丙胺（0.5 mg/kg）。结果：大鼠每48小时重复给药MDPV (1 mg/kg)，但不是每24小时给药一次，随后给药MDPV （0.5 mg/kg）或甲基苯丙胺（0.5 mg/kg）时，运动活动增加，分别表明行为致敏和交叉致敏的发展。此外，大鼠每48小时重复给予甲基苯丙胺（1mg /kg），并没有对随后用MDPV （0.5 mg/kg）刺激的运动刺激作用表现出交叉敏化。结论：这些结果表明，特定的MDPV给药模式可能导致对随后的甲基安非他明暴露的行为反应的持久变化。
BACKGROUND: In recent years, there has been a dramatic increase in abuse of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV), often in combination with other illicit stimulants.PURPOSE: We sought to determine if repeated exposure to MDPV would produce sensitization to the motor stimulant effects of the drug, and whether cross-sensitization would develop with the stimulant effects of methamphetamine (METH).STUDY DESIGN: Male Sprague-Dawley rats were administered MDPV (1 or 5 mg/kg) or saline once daily for 5 days at 24 hour intervals, or were administered MDPV (1 mg/kg) or saline once daily for 5 days at 48 hour intervals. For cross-sensitization experiments, rats were administered METH (1 mg/kg) or MDPV (1 or 5 mg/kg) once daily for 5 days at 48 hour intervals, and following a 5 day incubation period, were given an acute challenge injection of either MDPV (0.5 mg/kg) or METH (0.5 mg/kg), respectively.RESULTS: Rats repeatedly administered MDPV (1 mg/kg) every 48 hours, but not every 24 hours, demonstrated increased motor activity when given either a subsequent challenge of MDPV (0.5 mg/kg i.p.) or METH (0.5 mg/kg), indicating the development of behavioral sensitization and cross-sensitization, respectively. Moreover, rats repeatedly administered METH (1 mg/kg) every 48 hours did not exhibit cross-sensitization to the motor stimulating effects of a subsequent challenge with MDPV (0.5 mg/kg).CONCLUSION: These results suggest that specific patterns of MDPV administration may lead to lasting changes in behavioral responses to subsequent METH exposure.