Reduction of inhibition in the inferior colliculus after inner hair cell loss
Reduction of inhibition in the inferior colliculus after inner hair cell loss
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DOI：
10.1097/01.wnr.0000234754.11431.ee
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发表时间：
2006-10-02
期刊：
影响因子：
1.7
通讯作者：
Smolders, Jean W. T.
中科院分区：
文献类型：
--
作者：
Alkhatib, Ala;Biebel, Ulrich W.;Smolders, Jean W. T.
本实验观察了卡铂致内毛细胞部分缺失对同一灰鼠下丘中央核神经元率-水平功能的影响。部分内毛细胞的损失只造成一个小的升高的反应阈值，但诱导的比例单调和非单调率水平函数的比例显着增加，在210多个单位的特征频率的显着下降。这表明感觉传入阻滞后下丘的抑制作用降低。我们的结论是，一些功能的变化报告在听觉皮层外周传入神经阻滞后，已经实现了下丘的水平。
Effects of carboplatin-induced partial loss of inner hair cells on rate-level functions of neurons in the central nucleus of the inferior colliculus of the same chinchillas before and 1-3 months after carboplatin treatment were examined. Partial inner hair cell loss caused only a small elevation of response thresholds but induced a significant increase in the proportion of monotonic and a significant decrease in the proportion of non-monotonic rate-level functions at the characteristic frequency of 210 multiunits. This indicates that inhibition in the inferior colliculus is reduced after sensory deafferentation. We conclude that some of the functional changes reported in the auditory cortex after peripheral deafferentation are already realized at the level of the inferior colliculus.