Relapse after systemic treatment in paediatric morphoea
Relapse after systemic treatment in paediatric morphoea
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小儿硬斑病全身治疗后复发
DOI：
10.1111/j.1365-2133.2011.10535.x
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发表时间：
2012
影响因子：
10.3
通讯作者：
E. Pope
中科院分区：
文献类型：
--
作者：
L. Mirsky;A. Chakkittakandiyil;R. Laxer;C. O'Brien;E. Pope
据报道，80%的衰老迹象是由光型引起的，并且迹象的类型和强度可能根据受试者的光型而不同。在暴露于阳光的皮肤区域，主要在I/II型光型中观察到皮肤变薄、萎缩和毛细血管扩张。在合并症方面，慢性肾衰竭的患病率为24%。通过多变量分析发现，严重慢性肾功能衰竭是唯一一个与年龄无关的因素，可显著增加患皮肤疏松症的风险超过5倍。除了血液透析患者常见的瘙痒症外，终末期肾病患者还经常报告非特异性皮肤病变，如干燥症、色素沉着过度和血肿。最后两种也可在最晚期的皮肤疏松症中观察到，但严重慢性肾脏疾病和皮肤疏松症之间的关系尚没有明确的解释。总之，本研究表明，在虚弱的住院老年患者中，与年龄相关的皮肤疏松症的患病率较高，并且存在与年龄无关的严重慢性肾衰竭。随着全球人口老龄化，骨质疏松症可能成为一个公共卫生问题。应在前瞻性、精心设计的临床试验中开发和评估有效和安全的预防和治疗性治疗方法，以便随后对老年人和体弱者进行给药。
posure is reported to be responsible for 80% of ageing signs, and type and intensity of signs may differ according to the subject’s phototype. On sun-exposed skin areas, thinness, atrophy and telangiectasia are mainly observed in phototype I ⁄ II. In terms of comorbidities, the prevalence of chronic renal failure was 24%. Severe chronic renal failure was the only age-independent factor found to increase significantly the risk of dermatoporosis more than five-fold by multivariate analysis. Besides pruritus, which is common in haemodialysis patients, nonspecific skin lesions such as xerosis, hyperpigmentation and haematomas are often reported in patients with end-stage renal disease. The last two are also observed in the most advanced stages of dermatoporosis, but there is no clear explanation for the association between severe chronic renal disease and dermatoporosis. In conclusion, this study shows a high prevalence of dermatoporosis associated with age in frail hospitalized elderly patients and the presence of age-independent severe chronic renal failure. With an ageing population worldwide, dermatoporosis is likely to become a public health issue. Effective and safe preventive and curative treatments of dermatoporosis should be developed and evaluated in prospective, welldesigned clinical trials for administration subsequently to elderly and frail individuals.