N-Methyl-d-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions
N-Methyl-d-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions
复制标题
N-甲基-d-天冬氨酸受体拮抗剂 MK-801 诱导单侧纹状体缺血性病变或黑质 6-羟基多巴胺病变大鼠的转圈行为
DOI：
10.1007/bf00228583
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发表时间：
2004
影响因子：
12.7
通讯作者：
Y. Ushio
中科院分区：
文献类型：
--
作者：
S. Goto;K. Korematsu;N. Inoue;Kazumichi Yamada;T. Oyama;S. Nagahiro;Y. Ushio
本研究表明，选择性非竞争性N-甲基-D-天冬氨酸拮抗剂MK-801[(+)-5-甲基-10，11-二羟基-5H-二苯并(a，d)-环庚烯-5，10-亚胺]可剂量依赖性地诱导单侧纹状体损伤大鼠或6-羟基多巴胺所致单侧黑质损伤大鼠的自旋旋转行为。与基底节-丘脑皮质‘运动’回路的功能模型相关，本数据提示纹状体可能是MK-801在基底节活动的最重要的部位之一，它负责动物模型的旋转行为。
The present study shows that systemic administration of the selective, non-competitiveN-methyl-d-aspartate antagonist MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)-cyclohepten-5,10-imine] dose-dependently induces ipsiversive rotational behavior in the rats with a unilateral striatal lesion produced by transient middle cerebral artery occlusion or in those with a unilateral nigrostriatal lesion produced by 6-hydroxydopamaine. In relation to a functional model of the basal ganglia-thalamocortical ‘motor’ circuit, the present data suggest that the striatum may be one of the most important sites where MK-801 acts in the basal ganglia, with its being responsible for the circling behavior of the animal models.