Chinese medicine and its modernization demands
Chinese medicine and its modernization demands
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DOI：
10.1016/j.arcmed.2007.09.011
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发表时间：
2008-02-01
影响因子：
7.7
通讯作者：
Chen, Jian
中科院分区：
文献类型：
--
作者：
Li, Wei-Feng;Jiang, Jian-Guo;Chen, Jian
中药作为一种典型的天然药物，经过几千年的发展，积累了丰富的人类药理信息和经验，形成了完整的理论体系。但产品质量不高、法规和标准不达标、基础研究力度不够等问题制约了其在国际上的进一步发展和接受。本文介绍了中药材的起源和发展历史、中药材涉及的种类及其在生物分类中的分布。根据现状和存在的问题，认为中医药现代化已成为当务之急。中药现代化是指中医药与现代技术、现代学术思想、现代科学文化的结合，其中最重要的是阐明中药的有效成分，特别是复方的物质基础及其药效学机制。分析化学技术(高效液相、高效毛细管电泳法、高效毛细管电泳法等)分子生物学(膜片钳、基因钳、基因芯片、荧光探针、DNA末端标记、原位杂交等)是实现中医药现代化的有用工具。在这些研究和成果的基础上，再加上计算机技术，所有的中医药产品都将实现数字化和规范化。中医药现代化将为世界提供有关传统医药的有用参考信息。(C)2008年管理和社会保障制度。由爱思唯尔公司出版。
As a typical naturally derived drug, traditional Chinese medicine (TCM) has developed for several thousands of years and accumulated abundant human pharmacological information and experience to form an integrated theory system. However, the problems of lower product quality, substandard codes and standards, and under-enhancement of fundamental research have restricted its further development and acceptance internationally. In this review, we explain the origin and developmental history of TCM, species involved in TCM, and their distributions in biotaxy. According to the status and problems, it is concluded that TCM modernization has become necessary and urgent. Modernization of TCM means the combination of TCM with modem technology, modem academic thoughts, and modern scientific culture, in which the most important point is to elucidate the active component of TCM, especially the material foundation of compound prescriptions and their pharmacodynamic mechanisms. Technology of analytical chemistry (HPLC, HPCE, HSCCC, etc.) and molecular biology (patch clamp, gene clamp, gene chip, fluorescent probe, DNA TUNEL assay, in situ hybridization, etc.) are useful tools to realize the modernization of TCM. Based on those studies and achievements and coupled with computer technology, all TCM products will achieve digitalization and normalization. TCM modernization will provide the world with useful reference information on traditional medicines. (C) 2008 IMSS. Published by Elsevier Inc.