Inflammatory bowel disease serology in Asia and the West
Inflammatory bowel disease serology in Asia and the West
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DOI：
10.3748/wjg.v19.i37.6207
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发表时间：
2013-10-07
影响因子：
4.3
通讯作者：
Dotan, Iris
中科院分区：
文献类型：
--
作者：
Prideaux, Lani;Kamm, Michael A.;Dotan, Iris
目的：研究澳大利亚和香港地区高加索人和亚洲人的健康状况和炎症性肠病的血清学抗体。方法：对澳大利亚和香港的炎症性肠病患者及其正常亲属和健康对照组(中国)进行抗糖链抗体[抗壳糖苷、抗层粘连生物苷]、抗甘露糖苷、抗酿酒酵母(GASCA)和非典型核周抗中性粒细胞胞浆抗体(PANCA)的检测。结果：共调查90例受试者，其中克罗恩病(CD)21例，溃疡性结肠炎(UC)32例，健康对照29例，IBD患者亲属8例。48名受试者为澳大利亚人(29名高加索人，19名汉族)和42名香港人(均为汉族人)。与UC和健康人相比，高加索CD患者GASCA(67%vs3%，P&t；0.001)、ALCA(44%vs6%，P=0.005)和AMCA(67%vs15%，P=0.002)抗体阳性率显著升高，而HKCD患者仅AMCA抗体患病率(58%vs25%，P=0.035)。高加索人CD患者的GASSCA患病率(67%比0%，P<；0.001)和滴度(中位数59比9，P=0.002)显著高于香港CD患者。ALCA、ACCA和AMCA的患病率和滴度在两国CD中没有差异。高加索人中至少有一种抗体的出现高于香港CD患者(100%vs58%，P=0.045)。结论：香港、亚洲和澳大利亚高加索患者的血清学CD反应不同。不同的遗传、环境或疾病致病因素可能解释了这些差异。(C)2013年白石登。版权所有。
AIM: To study serological antibodies in Caucasians and Asians, in health and inflammatory bowel disease (IBD), in Australia and Hong Kong (HK).METHODS: Anti-glycan antibodies [anti-chitobioside (ACCA), anti-laminaribioside (ALCA)], and anti-mannobioside (AMCA), anti-Saccharomyces cervisiae (gASCA); and atypical perinuclear anti-neutrophil cytoplasmic antibody (pANCA) were tested in IBD patients, their unaffected relatives, and healthy controls in Australia and HK (China). Antibody status (positive or negative) and titre was compared between subjects of different geography, ethnicity and disease state.RESULTS: Ninety subjects were evaluated: 21 Crohn's disease (CD), 32 ulcerative colitis (UC), 29 healthy controls, and 8 IBD patient relatives. Forty eight subjects were Australian (29 Caucasian and 19 ethnic Han Chinese) and 42 were from HK (all Han Chinese). Caucasian CD patients had a significantly higher antibody prevalence of gASCA (67% vs 3%, P < 0.001), ALCA (44% vs 6%, P = 0.005), and AMCA (67% vs 15%, P = 0.002), whereas HK CD patients had a higher prevalence of only AMCA (58% vs 25%, P = 0.035), when compared with UC and healthy subjects in both countries. Caucasian CD had significantly higher gASCA prevalence (67% vs 0%, P < 0.001) and titre (median 59 vs 9, P = 0.002) than HK CD patients. Prevalence and titres of ALCA, ACCA and AMCA did not differ between CD in the two countries. Presence of at least one antibody was higher in Caucasian than HK CD patients (100% vs 58%, P = 0.045). pANCA did not differ between countries or ethnicity.CONCLUSION: Serologic CD responses differ between HK Asian and Australian Caucasian patients. Different genetic, environmental or disease pathogenic factors may account for these differences. (C) 2013 Baishideng. All rights reserved.