Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
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Decidua衍生的基质细胞的转录组和调节图为早产中的基因发现提供了信息。
DOI：
10.1126/sciadv.abc8696
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发表时间：
2020-12
期刊：
影响因子：
13.6
通讯作者：
Nóbrega MA
中科院分区：
文献类型：
--
作者：
Sakabe NJ;Aneas I;Knoblauch N;Sobreira DR;Clark N;Paz C;Horth C;Ziffra R;Kaur H;Liu X;Anderson R;Morrison J;Cheung VC;Grotegut C;Reddy TE;Jacobsson B;Hallman M;Teramo K;Murtha A;Kessler J;Grobman W;Zhang G;Muglia LJ;Rana S;Lynch VJ;Crawford GE;Ober C;He X;Nóbrega MA
Functional annotations of a placental cell genome aid in identifying genes associated with preterm birth. While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in human cell types relevant to pregnancy and PTB. We generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction (promoter capture Hi-C) annotations of cultured primary decidua-derived mesenchymal stromal/stem cells and in vitro differentiated decidual stromal cells and developed a computational framework to integrate these functional annotations with results from a GWAS of gestational duration in 56,384 women. Using these resources, we uncovered additional loci associated with gestational duration and target genes of associated loci. Our strategy illustrates how functional annotations in pregnancy-relevant cell types aid in the experimental follow-up of GWAS for PTB and, likely, other pregnancy-related conditions.
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影响因子：
4.1
作者：
Kessler CA;Bachurski CJ;Schroeder J;Stanek J;Handwerger S
通讯作者：
Handwerger S
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
30.8
作者：
Finucane HK;Bulik-Sullivan B;Gusev A;Trynka G;Reshef Y;Loh PR;Anttila V;Xu H;Zang C;Farh K;Ripke S;Day FR;ReproGen Consortium;Schizophrenia Working Group of the Psychiatric Genomics Consortium;RACI Consortium;Purcell S;Stahl E;Lindstrom S;Perry JR;Okada Y;Raychaudhuri S;Daly MJ;Patterson N;Neale BM;Price AL
通讯作者：
Price AL
DOI：
10.1073/pnas.1706546114
发表时间：
2017-10-03
影响因子：
11.1
作者：
Garrido-Gomez, Tamara;Dominguez, Francisco;Simon, Carlos
通讯作者：
Simon, Carlos