The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
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DOI：
10.1016/j.jad.2011.08.006
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发表时间：
2011-12-01
影响因子：
6.6
通讯作者：
Boye, Birgitte
中科院分区：
文献类型：
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作者：
Elvsashagen, Torbjorn;Vera, Elsa;Boye, Birgitte
背景：最近有假说认为双相情感障碍与加速衰老有关。端粒功能障碍是衰老的生物标志物，它是由短端粒的负荷决定的，而不是由平均端粒长度决定的。据我们所知，短端粒的负荷在任何精神疾病中都没有报道。本研究的目的是检测短端粒的负荷和平均端粒长度及其与双相II型障碍（BD-II）患者的病程和抑郁发作次数的关系。28例患者（平均年龄= 34.8 +/- 7.7）和28名年龄、性别和教育程度相匹配的健康对照受试者（平均年龄= 34.8 +/- 9.2）。短端粒的负荷（端粒的百分比
Background: It has recently been hypothesized that bipolar disorders are associated with accelerated aging. Telomere dysfunction, a biomarker of aging, is determined by the load of short telomeres, rather than by the mean telomere length. To our knowledge, the load of short telomeres has not been reported in any psychiatric disorder. The aims of the study were to examine the load of short telomeres and the mean telomere length and their relationships with illness duration and lifetime number of depressive episodes in bipolar II disorder (BD-II).Methods: Twenty-eight patients (mean age = 34.8 +/- 7.7) with a DSM-IV diagnosis of BD-II and 28 healthy control subjects (mean age = 34.8 +/- 9.2) matched for age, sex, and education participated. The load of short telomeres (percentage of telomeres