Race/Ethnicity-Specific Disparities in Cancer Incidence, Burden of Disease, and Overall Survival Among Patients With Hepatocellular Carcinoma in the United States
Race/Ethnicity-Specific Disparities in Cancer Incidence, Burden of Disease, and Overall Survival Among Patients With Hepatocellular Carcinoma in the United States
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DOI：
10.1002/cncr.30103
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发表时间：
2016-08-15
期刊：
影响因子：
6.2
通讯作者：
Wong, Robert J.
中科院分区：
文献类型：
--
作者：
Ha, John;Yan, Melissa;Wong, Robert J.
背景技术背景：肝细胞癌（HCC）是美国癌症相关死亡增长最快的原因之一，不同种族之间的癌症发病率和生存率存在差异。本报告提供了对美国HCC趋势中种族特异性差异的最新分析。方法：这项基于人群的大型队列研究使用2003年至2011年的监测，流行病学和最终结果癌症登记数据进行，以调查HCC发病率和生存率的种族差异。采用Kaplan-Meier方法和多变量考克斯比例风险模型分析生存率。从2003年到2011年，亚洲人的HCC发病率最高，其次是黑人，西班牙裔和非西班牙裔白人。在同一时期，西班牙裔HCC发病率增加最多（+35.8%），而亚洲人则下降了5.5%。尽管年龄≥ 65岁的患者在所有人种/种族中的HCC发病率最高，但仅在65岁的患者中观察到亚洲人的HCC发病率较高，而在50至64岁的患者中，亚洲人、黑人和西班牙裔人的HCC发病率相似。亚洲人的总体5年HCC生存率最高（26.1%; 95%置信区间[CI]，24.5%-27.6%），黑人最低（21.3%; 95% CI，19.5%-23.1%）。在多变量回归分析中，亚洲人（风险比，0.83; 95%CI，0.79-0.87; P
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the fastest rising causes of cancer-related deaths in the United States, with disparities observed in cancer incidence and survival between ethnic groups. This report provides updated analyses on race-specific disparities in US HCC trends. METHODS: This large, population-based cohort study was conducted using Surveillance, Epidemiology, and End Results cancer registry data from 2003 to 2011 to investigate race-specific disparities in HCC incidence and survival. Survival was analyzed using Kaplan-Meier methods and multivariate Cox proportional-hazards models. RESULTS: From 2003 to 2011, Asians had the highest HCC incidence, followed by blacks, Hispanics, and non-Hispanic whites. During the same period, Hispanics had the greatest increase in HCC incidence (+35.8%), whereas Asians experienced a 5.5% decrease. Although patients aged >= 65 years had the highest HCC incidence among all racial/ethnic groups, the higher HCC incidence in Asians was observed only for patients ages 65 years, whereas HCC incidence among patients ages 50 to 64 years was similar among Asians, blacks, and Hispanics. The overall 5-year HCC survival rate was highest among Asians (26.1%; 95% confidence interval [CI], 24.5%-27.6%) and lowest among blacks (21.3%; 95% CI, 19.5%-23.1%). On multivariate regression, Asians (hazard ratio, 0.83; 95% CI, 0.79-0.87; P