Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases
Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases
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DOI：
10.1093/humrep/deg369
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发表时间：
2003-09-01
影响因子：
6.1
通讯作者：
Cohen, J
中科院分区：
文献类型：
--
作者：
Alikani, M;Cekleniak, NA;Cohen, J
背景：本研究试图确定辅助受孕后单卵双胞胎的危险因素。方法：对我们的体外受精/胚胎移植计划中发生的81例MZ双胎妊娠进行评估。这与同期4224例非MZ妊娠进行了比较。结果：MZ双胎发生率为1.88%(81/4305)。总共63%(51/81)的MZ妊娠还包括一个或多个其他植入物。MZ双胞胎与母亲年龄、父亲年龄、促性腺激素用量、雌二醇和孕酮峰值水平、收集的卵母细胞数和替换胚胎数无关。MZ双胞胎患者与非MZ多胎妊娠患者相比，有更多的辅助生殖尝试。Logistic回归分析表明，透明带在MZ双胞胎中发挥了作用，尽管不是很重要。已知胎盘形成的65例MZ病例中，24例为单羊水。这一发生率远远高于自然受孕后的发生率(P
Background: This study attempts to identify risk factors for monozygotic (MZ) twinning following assisted conception. Methods: Eighty-one MZ twinning pregnancies that occurred over a 7-year period in our IVF/embryo transfer programme were evaluated. These were compared with 4224 non-MZ pregnancies from the same period. Results: The overall incidence of MZ twinning was 1.88% (81/4305) of all clinical pregnancies. A total of 63% (51/81) of the MZ pregnancies included one or more other implantations as well. MZ twinning was unrelated to maternal age, paternal age, gonadotrophin dosage, peak estradiol and progesterone levels, number of oocytes collected, and number of embryos replaced. Patients with MZ twinning had significantly more attempts at assisted reproduction than those with non-MZ multiple pregnancy. A logistic regression analysis suggested a role, albeit not emphatic, for the zona pellucida in MZ twinning. Twenty-four of the 65 MZ cases with known placentation were monoamniotic. This incidence far exceeds that seen following spontaneous conception (P