The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
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DOI：
10.1016/j.bbagrm.2012.09.005
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发表时间：
2012-11
影响因子：
4.7
通讯作者：
Aronheim, Ami
中科院分区：
文献类型：
--
作者：
Darlyuk-Saadon, Ilona;Weidenfeld-Baranboim, Keren;Yokoyama, Kazunari K.;Hai, Tsonwin;Aronheim, Ami
JDP2, is a basic leucine zipper (bZIP) protein displaying a high degree of homology with the stress inducible transcription factor, ATF3. Both proteins bind to cAMP and TPA response elements and repress transcription by multiple mechanisms. Histone deacetylases (HDACs) play a key role in gene inactivation by deacetylating lysine residues on histones. Here we describe the association of JDP2 and ATF3 with HDACs 1, 2–6 and 10. Association of HDAC3 and HDAC6 with JDP2 and ATF3 occurs via direct protein-protein interactions. The N-terminal bZIP motif of JDP2 and ATF3 basic domain are necessary and sufficient for the interaction with HDACs in a manner that is independent of coiled-coil dimerization. Class I HDACs associate with the bZIP repressors via the DAC conserved domain whereas the Class IIb HDAC6 associates through its C-terminal unique binder of ubiquitin Zn finger domain. Both JDP2 and ATF3 are known to bind and repress the ATF3 promoter. MEF cells treated with histone deacetylase inhibitor, trichostatin A (TSA) display enhanced ATF3 transcription. ATF3 enhanced transcription is significantly reduced in MEF cells lacking both ATF3 and JDP2. Collectively, we propose that the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism.
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影响因子：
5.3
作者：
Jin, CY;Li, HJ;Yokoyama, KK
通讯作者：
Yokoyama, KK
影响因子：
--
作者：
Huang YC;Hasegawa H;Wang SW;Ku CC;Lin YC;Chiou SS;Hou MF;Wu DC;Tsai EM;Saito S;Yamaguchi N;Yokoyama KK
通讯作者：
Yokoyama KK
DOI：
10.1073/pnas.172511699
发表时间：
2002-10-15
影响因子：
11.1
作者：
Hook, SS;Orian, A;Eisenman, RN
通讯作者：
Eisenman, RN
影响因子：
9.2
作者：
Broder, YC;Katz, S;Aronheim, A
通讯作者：
Aronheim, A
影响因子：
5.3
作者：
Clocchiatti A;Florean C;Brancolini C
通讯作者：
Brancolini C