The impact of HIV on chronic kidney disease outcomes
The impact of HIV on chronic kidney disease outcomes
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DOI：
10.1038/sj.ki.5002541
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发表时间：
2007-12-01
影响因子：
19.6
通讯作者：
O'Hare, A. M.
中科院分区：
文献类型：
--
作者：
Choi, A. I.;Rodriguez, R. A.;O'Hare, A. M.
慢性肾脏病(CKD)是人类免疫缺陷病毒(HIV)的已知并发症，但HIV感染的肾病患者的预后尚不清楚。我们研究了全国范围内202927名CKD(3期或以上)患者的死亡、终末期肾病(ESRD)和估计肾小球滤过率(EGFR)在中位数3.8年期间的平均年递减率。在这个样本中，0.3%的患者被诊断出感染了艾滋病毒，43.5%的患者患有糖尿病，而其余的患者既没有疾病也没有疾病。在这一全国性的CKD队列中，感染艾滋病毒的黑人患者的死亡风险更高，与患有糖尿病的黑人患者相比，患ESRD和失去EGFR的风险相似。与糖尿病患者相比，感染艾滋病毒的白人患者的死亡率更高，但患ESRD的风险更低。我们的结果强调了研究HIV感染人群中ESRD的死亡率和机制的必要性。
Chronic kidney disease (CKD) is a known complication of the human immunodeficiency virus (HIV) but outcomes among HIV-infected patients with kidney disease are unknown. We studied a national sample of 202 927 patients with CKD (stage 3 or higher) for death, end-stage renal disease (ESRD) and the mean annual rate of decline in estimated glomerular filtration rate (eGFR) over a median period of 3.8 years. Within this sample, 0.3% of the patients were diagnosed with HIV, 43.5% were diabetic, whereas the remainder had neither disease. In this national CKD cohort, HIV-infected black patients were at higher risk of death, a similar risk for ESRD and loss of eGFR than black patients with diabetes. HIV-infected white patients experienced higher rates of death but a lower risk of ESRD than their counterparts with diabetes. Our results highlight a need to study mortality and mechanisms of ESRD in the HIV infected population.