Modeling drug-carrier interaction in the drug release from nanocarriers.
Modeling drug-carrier interaction in the drug release from nanocarriers.
复制标题
在纳米载体中释放药物释放中的药物载体相互作用。
DOI：
10.1155/2011/370308
复制
发表时间：
2011
影响因子：
--
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Zeng L;An L;Wu X
许多不同组成和几何结构的纳米载体已经被开发出来用于治疗和显像剂的输送和释放。由于纳米载体具有较高的比表面积，需要探索离子配对和疏水相互作用等不同的机制来实现缓释。最近，我们发展了一个三参数模型，该模型考虑了可逆的药物-载体相互作用和脂质体的一级药物释放。得到了闭合形式的解析解。在这里，我们进一步探索该模型捕捉各种纳米载体释放的生物活性分子，如药物和生长因子的能力。参数研究表明，该模型能够较好地模拟药物释放动力学的主要类型。我们进一步将该模型与来自不同药物释放系统的60组实验数据进行了拟合，包括纳米粒、中空颗粒、纤维和中空纤维。此外，还使用Bootstrapping来评估参数确定的准确性，并在选定的案例中对模型进行验证。该模型具有模型的简单性和通用性，各模型参数的物理意义明确，可用于新型给药系统的设计和开发。
Numerous nanocarriers of various compositions and geometries have been developed for the delivery and release of therapeutic and imaging agents. Due to the high specific surface areas of nanocarriers, different mechanisms such as ion pairing and hydrophobic interaction need to be explored for achieving sustained release. Recently, we developed a three-parameter model that considers reversible drug-carrier interaction and first-order drug release from liposomes. A closed-form analytical solution was obtained. Here, we further explore the ability of the model to capture the release of bioactive molecules such as drugs and growth factors from various nanocarriers. A parameter study demonstrates that the model is capable of resembling major categories of drug release kinetics. We further fit the model to 60 sets of experimental data from various drug release systems, including nanoparticles, hollow particles, fibers, and hollow fibers. Additionally, bootstrapping is used to evaluate the accuracy of parameter determination and validate the model in selected cases. The simplicity and universality of the model and the clear physical meanings of each model parameter render the model useful for the design and development of new drug delivery systems.