Phosphine Catalysis of the Fluorination of Unactivated Tertiary Alkyl Chlorides under Mild and Convenient Conditions.
Phosphine Catalysis of the Fluorination of Unactivated Tertiary Alkyl Chlorides under Mild and Convenient Conditions.
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DOI：
10.1021/jacs.3c11042
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发表时间：
2023-11
影响因子：
15
通讯作者：
Zhuo-Yan Wang;Dylan J Freas;Gregory C Fu
中科院分区：
文献类型：
--
作者：
Zhuo-Yan Wang;Dylan J Freas;Gregory C Fu
由于有机氟化合物在从医学到农业到材料科学的学科中的重要性，发明用于产生碳-氟键的新方法是一个重要目标。在这一领域的未开发的方面是受阻烷基卤化物（特别是氯化物）的分解和这种分解过程的催化剂的发现。在此，我们报告了一种温和的方法，用于未活化的叔烷基氯化物（和溴化物），廉价的PPh 3催化。这种简单的过程与一系列受阻亲电试剂和各种官能团兼容。
Due to the significance of organofluorine compounds in disciplines ranging from medicine to agriculture to materials science, the invention of new methods for the creation of carbon-fluorine bonds is an important objective. Among the underdeveloped dimensions in this area are the fluorination of hindered alkyl halides (particularly chlorides) and the discovery of catalysts for such fluorination processes. Herein, we report a mild method for the fluorination of unactivated tertiary alkyl chlorides (and bromides), catalyzed by inexpensive PPh3. This straightforward process is compatible with a range of hindered electrophiles and a variety of functional groups.