Editorial overview: Bioinorganic chemistry: Metals in biology: approaching the big picture
Editorial overview: Bioinorganic chemistry: Metals in biology: approaching the big picture
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编辑概述：生物无机化学：生物学中的金属：接近大局
DOI：
10.1016/j.cbpa.2020.03.002
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发表时间：
2020
影响因子：
7.8
通讯作者：
Michel, Sarah
中科院分区：
文献类型：
--
作者：
DeRose, Victoria;Michel, Sarah
在化学生物学最新观点的“生物无机化学”特刊中，我们提出了一系列评论文章，涵盖并弥合了生物学中金属的基本生物无机原理和“系统级”观点。这些评论分为三个一般领域：“生物学中金属和硫稳态的前沿”、“调节生物学的无机工具”和“生物学中系统级金属的进展”。从这些评论中，我们了解了简单到复杂生物体（细菌到人类）中无机物种的代谢、扰乱金属稳态的新方法以及对细胞中金属进行成像的最新方法，以回答有关金属调节的基本问题。 “生物学中金属和硫的稳态前沿”部分，我们从细菌开始。在此，Lauren Waters (https://www.sciencedirect.com/science/article/pii/S1367593120300041) 向我们介绍了锰稳态，描述了作为锰吸收门户的新锰转运蛋白及其调节剂，包括金属结合核糖开关，并提供了关于毒力中锰稳态调节以及共生的新见解。然后，评论扩展到真核生物，并从酵母中的两个故事开始，重点是破译锌和铁稳态的基本原理。在 Amanda Bird 的评论（https://www.sciencedirect.com/science/article/pii/S1367593120300120）中，她阐述了目前对锌饥饿和锌过载条件下锌如何在细胞器和蛋白质之间分配的理解，更新了锌转运蛋白在锌形态形成中的作用，并为细胞如何优先考虑在锌饥饿下结合锌的蛋白质以及细胞如何在锌过载期间缓冲过量的锌提供了想法。 Caryn Outten 的综述 (https://www.sciencedirect.com/science/article/pii/S1367593120300247) 介绍了非致病性和致病性酵母中的铁代谢机制。 Outten 描述了一组共同作用来调节铁的吸收、使用和储存的蛋白质，我们了解到 Fe-S 簇作为铁生物利用度的传感器发挥着核心作用。我们还了解到，不同酵母物种的调节途径涉及独特的蛋白质组合，反映了该物种对其环境生态位的适应。
In this special ‘Bioinorganic Chemistry’issue of Current Opinion in Chemical Biology, we present a series of review articles that encompass and bridge fundamental bioinorganic principles and ‘systems level’views of metals in biology. The reviews are divided into three general areas:‘Frontiers in the Homeostasis of Metals and Sulfur in Biology,’‘Inorganic Tools to Modulate Biology,’and ‘Advances in Systems Level Metals in Biology.’From these reviews, we learn about the metabolism of inorganic species in simple to complex organisms (bacteria to humans), novel approaches to perturb metal homeostasis and the latest ways to image metals in cells to answer fundamental questions regarding metal regulation.In the ‘Frontiers in the Homeostasis of Metals and Sulfur in Biology’section, we start with bacteria. Here, Lauren Waters (https://www. sciencedirect. com/science/article/pii/S1367593120300041) teaches us about manganese homeostasis, describes new manganese transporters that serve as gateways to manganese uptake and their regulators, including metal-binding riboswitches, and provides novel insights into modulation of manganese homeostasis in virulence, as well as symbiosis. The reviews then expand to eukaryotes and begin with two stories in yeast that focus on deciphering fundamental principles of zinc and iron homeostasis. In Amanda Bird’s review(https://www. sciencedirect. com/science/article/pii/S1367593120300120), she lays out the current understanding of how zinc is distributed among organelles and proteins under conditions of zinc starvation and zinc overload, updates us on the roles of zinc transporters in zinc speciation, and provides ideas for how cells prioritize the proteins that bind zinc under zinc starvation, and how cells buffer excess zinc during zinc overload. In Caryn Outten’s review (https://www. sciencedirect. com/science/article/pii/S1367593120300247), mechanisms of iron metabolism in nonpathogenic and pathogenic yeast are presented. Outten describes the ensemble of proteins that work together to regulate iron uptake, use and storage, and we learn that Fe-S clusters play a central role as sensors of iron bioavailability. We also learn that the regulation pathways for different yeast species involve unique combinations of proteins that reflect the species’ adaptations to their environmental niches.