Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress.
Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress.
复制标题
雌激素衍生的邻醌和对醌在诱导氧化应激方面的比较。
DOI：
10.1016/j.jsbmb.2006.11.025
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Prokai,Laszlo
中科院分区：
文献类型：
--
作者：
Rivera-Portalatin,NilkaM;Vera-Serrano,JoséL;Prokai-Tatrai,Katalin;Prokai,Laszlo
Ortho-quinones formed from catechol estrogens are considered prooxidants due to the production of superoxide radical anions through redox cycling via semiquinones. Para-quinols have been identified as novel metabolites of and as the major products of hydroxyl-radical scavenging by estrogens. Cycling of these compounds has also been discovered, because they are converted back to the parent estrogen via reductive aromatization in vitro and in vivo. We hypothesized that, unlike ortho-quinones, para-quinols do not induce oxidative stress due to this cycling. Like the estrogen itself, the 17β-estradiol-derived para-quinol (10β,17β-dihydroxyestra-1,4-diene-3-one) did not induce oxidative stress, as the rate of hydrogen peroxide production during the incubations of the compounds in various tissue homogenates was not significantly different from that of the control experiments performed without the addition of a test compound. We also confirmed that the estrogen metabolite estra-1,5(10)-dien-3,4,17-trione (estrone 3,4-quinone) was a profound prooxidant due to redox cycling, especially in uterine tissue. Therefore, we concluded that para-quinols do not induce oxidative stress.
