Secondary metabolites from the endophytic fungus Biscogniauxia formosana and their antimycobacterial activity
Secondary metabolites from the endophytic fungus Biscogniauxia formosana and their antimycobacterial activity
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DOI：
10.1016/j.phytol.2012.04.007
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Chen, Jih-Jung
中科院分区：
文献类型：
--
作者：
Cheng, Ming-Jen;Wu, Ming-Der;Chen, Jih-Jung
从药用植物肉桂（Cinnamomum species）树皮中的内生真菌Biscogniauxia formosana BCRC 33718发酵的长粒米95%乙醇提取物的正丁醇可溶性部分中分离得到两个新的氮杂菲酮衍生物，即biscogniaazaphilones A（1）和B（2），沿着10个已知化合物（3-12）。通过1D和2D NMR、HRESIMS、ESIMS、UV和IR等波谱分析手段，并与文献数据进行比较，确定了化合物的结构。此外，评价分离的化合物（1-12）的抗分枝杆菌活性。两个新的化合物biscogniazaphilones A（1）和B（2）对结核分枝杆菌H（37）Rv株的抗菌活性最强，MIC值分别为5.12和2.52 μ g/mL。(C)2012欧洲植物化学学会。Elsevier B. V.出版，保留所有权利。
Two new azaphilone derivatives, namely, biscogniazaphilones A (1) and B (2), along with ten known compounds (3-12), were isolated from the n-BuOH-soluble fraction of the 95% EtOH extract of long-grain rice fermented with the endophytic fungus Biscogniauxia formosana BCRC 33718, derived from the bark of medicinal plant Cinnamomum species. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR as well as HRESIMS, ESIMS, UV, and IR, and comparison with literature data. In addition, the isolated compounds (1-12) were evaluated for their antimycobacterial activity. Two new constituents, biscogniazaphilones A (1) and B (2), exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 5.12 and 2.52 mu g/mL, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.