Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance?
Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance?
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DOI：
10.1055/s-2007-978828
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发表时间：
1998-01-01
影响因子：
2.2
通讯作者：
Koivisto, V
中科院分区：
文献类型：
--
作者：
Eriksson, J;Tuominen, J;Koivisto, V
身体活动在预防非胰岛素依赖型糖尿病（NIDDM）中的作用至关重要。本研究的目的是评价有氧耐力运动和循环式抗阻训练对糖耐量减低（IGT）受试者代谢的影响。22人参加了这项研究。14名受试者参加了这项研究的有氧耐力运动部分; 7名定期锻炼6个月，7名作为对照。测量最大有氧能力（V/dot O（2）max），通过频繁采样的静脉葡萄糖耐量试验（FSIVGTT）评估胰岛素敏感性和胰岛素分泌。八名受试者参加了为期三个月的电路式阻力训练计划。然后采用正葡萄糖胰岛素钳夹技术结合间接量热法评估胰岛素敏感性和底物氧化。有氧耐力运动项目导致氧（2）max（21.6 +/- 1.9至25.4 +/- 2.4 ml/kg.min; p < 0.05）和HDL-胆固醇（1.14 +/- 0.06至1.23 +/- 0.08 mmol/l; p < 0.05）增加，但胰岛素敏感性和胰岛素分泌没有变化。但干预组与对照组比较，差异消失。回路型阻力训练使胰岛素敏感性（葡萄糖处理）增加了23%（p < 0.05），主要是由于非氧化葡萄糖代谢增加了27%。回路型阻力训练和有氧耐力运动似乎对糖耐量受损的受试者有有益的影响。然而，通过改善胰岛素敏感性，回路型阻力训练可能会推迟这些高危人群的NIDDM表现，因此应纳入IGT受试者的运动计划。
The role of physical activity in the prevention of non-insulin-dependent diabetes mellitus (NIDDM) is of utmost importance. The aim of the present study was to evaluate the metabolic effects of aerobic endurance exercise and circuit-type resistance training in subjects with impaired glucose tolerance (IGT). Twenty-two individuals participated in the study. Fourteen subjects were enrolled in the aerobic endurance exercise part of the study; seven exercised regularly for six months, while seven served as controls. Maximal aerobic capacity ((V) over dot O(2)max) was measured and insulin sensitivity and insulin secretion were assessed by a frequently sampled intravenous glucose tolerance test (FSIVGTT). Eight subjects participated in a circuit-type resistance training program for three months. Insulin sensitivity and substrate oxidation were then assessed using the euglycemic insulin clamp technique combined with indirect calorimetry. The aerobic endurance exercise program caused an increase in (V) over dot O(2)max (21.6 +/- 1.9 to 25.4 +/- 2.4 ml/kg.min; p < 0.05) and HDL-cholesterol (1.14 +/- 0.06 to 1.23 +/- 0.08 mmol/l; p < 0.05), but no change in insulin sensitivity nor insulin secretion occurred. However, comparing the changes between the intervention and control group, the differences disappeared. Circuit-type resistance training increased insulin sensitivity (glucose disposal) by 23% (p < 0.05), primarily due to a 27% increase in non-oxidative glucose metabolism. Both circuit-type resistance training and aerobic endurance exercise seem to have beneficial effects in subjects with impaired glucose tolerance. However, by improving insulin sensitivity, circuit-type resistance training may postpone the manifestations of NIDDM in these high-risk individuals and should therefore be included in an exercise program for IGT subjects.