RECOVERY FROM WERNICKES APHASIA - A POSITRON EMISSION TOMOGRAPHIC STUDY
RECOVERY FROM WERNICKES APHASIA - A POSITRON EMISSION TOMOGRAPHIC STUDY
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DOI：
10.1002/ana.410370605
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发表时间：
1995-06-01
影响因子：
11.2
通讯作者：
DIENER, HC
中科院分区：
文献类型：
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作者：
WEILLER, C;ISENSEE, C;DIENER, HC
失语症恢复后的大脑组织的变化进行了研究，通过测量增加局部脑血流量（rCBF）在重复的假词和动词的产生。6名右利手患者，他们从因梗死破坏左后外侧裂周围语言区而导致的韦尼克失语症中恢复过来，并与6名健康的右利手志愿者进行了比较。在对照组中，强烈的rCBF增加被发现在左半球的后部的上级和颞中回（韦尼克区），并在生成任务在外侧前额叶皮层（LPFC）和额下回（布罗卡区）。右半球的上级颞回和下运动前皮质有一些微弱的增加。在患者中，rCBF增加保留在额叶区域。右半球的上级颞回、下运动前区和外侧前额叶皮层明显激活，与左半球的语言区同位置。在韦尼克区持续破坏的患者中，左额叶和右侧裂周活动增加强调了在预先存在的平行处理和双侧网络的框架内活动的重新分布，这是中风后语言系统功能重组的中心机制。
Changes in the organization of the brain after recovery from aphasia were investigated by measuring increases in regional cerebral blood flow (rCBF) during repetition of pseudowords and during verb generation. Six right-handed patients who had recovered from Wernicke's aphasia caused by an infarction destroying the left posterior perisylvian language zone were compared with 6 healthy, right-handed volunteers. In the control subjects, strong rCBF increases were found in the left hemisphere in the posterior part of the superior and middle temporal gyrus (Wernicke's area), and during the generation task in lateral prefrontal cortex (LPFC) and in inferior frontal gyrus (Broca's area). There were some weak right hemisphere increases in superior temporal gyrus and inferior premotor cortex. In the patients, rCBF increases were preserved in the frontal areas. There was clear right hemisphere activation in superior temporal gyrus and inferior premotor and lateral prefrontal cortices, homotopic to the left hemisphere language zones. Increased left frontal and right perisylvian activity in patients with persisting destruction of Wernicke's area emphasizes redistribution of activity within the framework of a preexisting, parallel processing and bilateral network as the central mechanism in functional reorganization of the language system after stroke.