Release of norepinephrine from the paraventricular hypothalamic nucleus of hypertensive rats.
Release of norepinephrine from the paraventricular hypothalamic nucleus of hypertensive rats.
复制标题
高血压大鼠下丘脑室旁核释放去甲肾上腺素。
DOI：
10.1152/ajpheart.1988.254.5.h993
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Westfall,TC
中科院分区：
文献类型：
--
作者：
Qualy,JM;Westfall,TC
使用推拉插管检查未麻醉、自由活动的 7 至 10 周和 12 至 14 周龄 Sprague-Dawley (SD)、Wistar-Kyoto (WKY) 和自发性高血压 (SHR) 大鼠室旁下丘脑核 (PVH) 的内源性去甲肾上腺素 (NE) 释放情况。在两个年龄段的所有三个菌株中检查了基础 NE 释放、K+ (56 mM) 刺激诱导的 NE 释放以及响应升压/抑制药物的 NE 释放。与血压正常的对照大鼠相比，在 7 至 10 周和 12 至 14 周龄的 SHR 中观察到 PVH 的基础和 K+刺激的内源性 NE 释放显着增加，这表明中枢去甲肾上腺素能神经活动的增强可能与 SHR 中高血压的发生和维持有关。此外，血压和 PVH 的 NE 释放存在相互关系，即，在两个年龄组的所有三种菌株中，血压降低会导致 NE 释放增加，而血压升高会导致 NE 释放减少，这表明 PVH 的去甲肾上腺素能途径有助于维持动脉血压稳态。
The push-pull cannula was used to examine the release of endogenous norepinephrine (NE) from the paraventricular hypothalamic nucleus (PVH) of unanesthetized freely moving 7- to 10- and 12- to 14-wk-old Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive (SHR) rats. Basal NE release, K+ (56 mM) stimulation-induced NE release, and NE release in response to pressor/depressor drugs were examined in all three strains at both ages. Significant increases in basal and K+-stimulated release of endogenous NE from the PVH were observed in 7- to 10- and 12- to 14-wk-old SHR compared with the normotensive control rats suggesting that enhanced central noradrenergic nerve activity may be involved in the development and maintenance of hypertension in the SHR. In addition, a reciprocal relationship exists with respect to blood pressure and NE release from the PVH, i.e., decreases in blood pressure elicit increases in NE release, and increases in blood pressure elicit decreases in NE release in all three strains at both age groups, suggesting that the noradrenergic pathways of the PVH contribute to the maintenance of arterial blood pressure homeostasis.