ESTROGEN-RECEPTOR EXPRESSION IN DUCTAL CARCINOMA INSITU OF THE BREAST - RELATIONSHIP TO FLOW CYTOMETRIC ANALYSIS OF DNA AND EXPRESSION OF THE C-ERBB-2 ONCOPROTEIN
ESTROGEN-RECEPTOR EXPRESSION IN DUCTAL CARCINOMA INSITU OF THE BREAST - RELATIONSHIP TO FLOW CYTOMETRIC ANALYSIS OF DNA AND EXPRESSION OF THE C-ERBB-2 ONCOPROTEIN
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DOI：
10.1038/bjc.1993.305
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发表时间：
1993-07-01
影响因子：
8.8
通讯作者：
ELLIS, IO
中科院分区：
文献类型：
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作者：
POLLER, DN;SNEAD, DRJ;ELLIS, IO
使用单克隆抗体 H 222 (Abbott)，通过免疫细胞化学测定 (ERICA) 在福尔马林固定石蜡包埋的组织中检查 151 例有症状或筛查检测到的纯乳腺导管原位癌 (DCIS) 中雌激素受体蛋白 (ER) 的表达。 48 例肿瘤（31.8%）的病例呈 ER 阳性。 27 例 (17.9%) 病例显示高水平 ER 表达，21 例 (13.9%) 病例显示低水平 ER 免疫反应性。阳性肿瘤 ER 免疫反应性与非粉刺结构 chi2 = 6.76 显着相关； (d.f. = 1)：P < 0.001，小细胞尺寸 chi2 = 4.49； (d.f. = 1)：P = 0.034，较高的 S 相分数 chi2 = 4.71； (d.f. = 1)：P = 0.03，且缺乏 c-erbB-2 蛋白过度表达 chi2 = 7.96； （d.f. = 1）：P
The expression of oestrogen receptor protein (ER) was examined in 151 cases of symptomatic or screening detected pure ductal carcinoma in situ (DCIS) of the breast by immunocytochemical assay (ERICA), in formalin-fixed paraffin-embedded tissue, with the monoclonal antibody H 222 (Abbott). Forty-eight tumours (31.8%) of cases were ER positive. Twenty-seven (17.9%) of cases showed high level ER expression and 21 (13.9%) of cases showed low level ER immunoreactivity. Significant associations of positive tumour ER immunoreactivity and non-comedo architecture chi2 = 6.76; (d.f. = 1): P < 0.001, small cell size chi2 = 4.49; (d.f. = 1): P = 0.034, higher S-phase fraction chi2 = 4.71; (d.f. = 1): P = 0.03 and lack of c-erbB-2 protein overexpression chi2 = 7.96; (d.f. = 1): P