Multi-modal normalization of resting-state using local physiology reduces changes in functional connectivity patterns observed in mTBI patients
Multi-modal normalization of resting-state using local physiology reduces changes in functional connectivity patterns observed in mTBI patients
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DOI：
10.1016/j.nicl.2020.102204
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Cook, Douglas J.
中科院分区：
文献类型：
--
作者：
Champagne, Allen A.;Coverdale, Nicole S.;Cook, Douglas J.
血氧水平依赖性（BOLD）静息态功能磁共振成像（rs-fMRI）可以作为一个敏感的标记，以确定在轻度创伤性脑损伤（mTBI）后的大规模网络的架构可能发生的变化。然而，来自BOLD rs-fMRI的功能连接性（FC）测量的差异可能会受到局部脑血管生理学和神经血管耦合机制变化的干扰，而不会改变潜在的神经驱动的网络连接。在这项研究中，多模态神经影像学数据，包括BOLD rs-fMRI，基线脑血流量（CBF 0）和脑血管反应性（CVR;使用高碳酸气体呼吸挑战获得），收集了23名受试者报告的mTBI（14.6 +/- 14.9个月后受伤）和27名年龄匹配的健康对照。尽管在感兴趣的网络内CVR没有组间差异（P > 0.05，校正），但相对于对照组，在mTBI受试者中记录到显著更高的CBF 0（P < 0.05，校正）。引入了一种归一化方法，旨在解释mTBI后CBF 0的差异，以评估这种方法对报告的网络连接组差异的影响。在计算大规模网络内和跨网络的相关系数时纳入区域灌注测量缩小了组间FC的差异，表明这种方法可以阐明mTBI后连接性的独特变化，同时解释与CBF 0的共享方差。总而言之，我们的研究结果提供了一个强有力的范例，支持需要考虑BOLD的生理调节剂的变化，以扩大我们对脑损伤对皮层网络大规模FC的影响的理解。
Blood oxygenation level dependent (BOLD) resting-state functional magnetic resonance imaging (rs-fMRI) may serve as a sensitive marker to identify possible changes in the architecture of large-scale networks following mild traumatic brain injury (mTBI). Differences in functional connectivity (FC) measurements derived from BOLD rs-fMRI may however be confounded by changes in local cerebrovascular physiology and neurovascular coupling mechanisms, without changes in the underlying neuronally driven connectivity of networks. In this study, multimodal neuroimaging data including BOLD rs-fMRI, baseline cerebral blood flow (CBF0) and cerebrovascular reactivity (CVR; acquired using a hypercapnic gas breathing challenge) were collected in 23 subjects with reported mTBI (14.6 +/- 14.9 months post-injury) and 27 age-matched healthy controls. Despite no group differences in CVR within the networks of interest (P > 0.05, corrected), significantly higher CBF0 was documented in the mTBI subjects (P < 0.05, corrected), relative to the controls. A normalization method designed to account for differences in CBF0 post-mTBI was introduced to evaluate the effects of such an approach on reported group differences in network connectivity. Inclusion of regional perfusion measurements in the computation of correlation coefficients within and across large-scale networks narrowed the differences in FC between the groups, suggesting that this approach may elucidate unique changes in connectivity post-mTBI while accounting for shared variance with CBF0. Altogether, our results provide a strong paradigm supporting the need to account for changes in physiological modulators of BOLD in order to expand our understanding of the effects of brain injury on large-scale FC of cortical networks.