Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
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DOI：
10.1161/01.cir.104.3.358
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发表时间：
2001-07-17
期刊：
影响因子：
37.8
通讯作者：
Eriksson, U
中科院分区：
文献类型：
--
作者：
Aase, K;von Euler, G;Eriksson, U
背景-血管内皮生长因子（vegf）及其受体是胚胎和成人血管生成和血管生成的重要调节因子。其中一个生理功能未知的因子是VEGF-B，它在包括心脏在内的许多组织中表达。方法与结果-培养了VEGF-B基因靶向缺失小鼠。在VEGF-B动物中，正常情况下VEGF-B高表达的器官（如心脏、肌肉和肾脏）未观察到明显异常。心电功能分析显示，成年VEGF-B-/-小鼠心房传导异常，PQ间期延长。VEGF-或碱性成纤维细胞生长因子诱导的角膜血管生成在正常小鼠和VEGF- b -/-小鼠中相似。结论：VEGF-B似乎是成年动物正常心脏功能所必需的，但无论是在发育过程中还是在成人血管生成过程中，心血管系统的正常发育都不需要VEGF-B。
Background - Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart.Methods and Results - Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B-/- mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B-/- mice.Conclusions - VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.