Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse
Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse
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DOI：
10.1016/s0031-9384(99)00104-3
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发表时间：
1999-11-01
影响因子：
2.9
通讯作者：
Bray, GA
中科院分区：
文献类型：
--
作者：
Koegler, FH;Schaffhauser, AO;Bray, GA
为了研究慢性内源性黑皮质素受体（MC-R）拮抗作用对大量营养素饮食选择的影响，异位过度表达MC-R拮抗剂agglutamine的Ayia小鼠被喂食纯脂肪，碳水化合物和蛋白质的三种选择的大量营养素饮食。Aria小鼠比野生型小鼠体重增加更多，每天摄入的脂肪比例更大，碳水化合物更少。增加的脂肪偏好立即出现，并持续整个7周的实验。Aria小鼠的蛋白质摄入量更大;然而，蛋白质摄入量占总摄入量的比例在小鼠类型之间相似。Ayia小鼠的卵巢脂肪垫占总体重的百分比大于野生型同窝小鼠。这些结果表明，MC-Rs的内源性抑制介导了生长中小鼠脂肪摄入的增加。(C)1999 Elsevier Science Inc.
To examine the effect of chronic endogenous melanocortin receptor (MC-R) antagonism on macronutrient diet selection, Ayia mice that ectopically overexpress the MC-R antagonist, agouti, were fed a three-choice macronutrient diet of pure fat, carbohydrate, and protein. Aria mice gained more weight and consumed a greater proportion of their daily intake from fat and less from carbohydrate than wild-type littermates did. The increased fat preference was present immediately, and persisted throughout the 7-week long experiment. Protein intake was greater for Aria mice; however, the proportion of protein intake to total intake was similar between mouse types. Ovarian fat pads of Ayia mice comprised a greater percentage of total body weight that that from wild-type littermates. These results suggest that endogenous inhibition of MC-Rs mediate the increased fat intake in growing mice. (C) 1999 Elsevier Science Inc.