Racial differences in prostate androgen levels in men with clinically localized prostate cancer
Racial differences in prostate androgen levels in men with clinically localized prostate cancer
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DOI：
10.1097/01.ju.0000127739.88383.79
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发表时间：
2004-06-01
影响因子：
6.6
通讯作者：
Petrusz, P
中科院分区：
文献类型：
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作者：
Mohler, JL;Gaston, KE;Petrusz, P
目的：研究前列腺组织微环境中雄激素刺激是否存在种族差异。材料和方法：从36例美国黑人和59例白人前列腺癌根治术标本中提取类固醇激素。用放射免疫法测定睾酮、双氢睾酮(DHT)、雄烯二酮(ASD)、脱氢表雄酮、脱氢表雄酮硫酸盐、性激素结合球蛋白(SHBG)和前列腺特异性抗原(PSA)。采用Wilcoxon 2组试验比较美国白人和黑人的临床特征和组织类固醇水平。结果：美国黑人和白人在血清PSA、病理分级和分期方面相似。然而，黑人男性更年轻(p=0.01)，体重指数明显更高(p=0.02)。黑人和白人男性的睾丸激素和二羟色胺水平相似。然而，黑人男性的ASD(p=0.006)和SHBG(p=0.009)更高。在控制了年龄、体重指数、前列腺特异性抗原、病理Gleason和分期后，ASD(p=0.015)和SHBG(p=0.008)的种族差异仍然存在。结论：睾酮和双羟色胺的组织水平没有种族差异。然而，黑人男性的组织ASD和SHBG高于白人男性。在黑人男性的前列腺中，较高的组织ASD并不会导致ASD向睾酮的更大转化。高等组织SHBG可能通过环磷酸腺苷依赖途径激活雄激素受体。
Purpose: We sought to determine whether there are racial differences in androgenic stimulation within the prostate tissue microenvironment.Materials and Methods: Steroid hormones were extracted from snap frozen tissue obtained intraoperatively from radical prostatectomy specimens of 36 black and 59 white Americans. Testosterone, dihydrotestosterone (DHT), androstenedione (ASD), dehydroepiandrosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG) and prostate specific antigen (PSA) were measured using radioimmunoassay. The Wilcoxon 2 group test was performed to compare clinical characteristics and tissue steroid levels between white and black Americans. Nonparametric rank ANOVA was used to consider race and other clinical factors in a multivariable way.Results: Black and white American men were similar with respect to serum PSA, and pathological grade and stage. However, black men were younger (p = 0.01) and had a significantly higher body mass index (p = 0.02). Black and white men had similar testosterone and DHT. However, black men had higher ASD (p = 0.006) and SHBG (p = 0.009). Racial differences in ASD (p = 0.015) and SHBG (p = 0.008) persisted after controlling for age, body mass index, PSA, and pathological Gleason sum and stage.Conclusions: Tissue levels of testosterone and DHT did not differ by race. However, black men had higher tissue ASD and SHBG than white men. Higher tissue ASD did not result in a greater conversion of ASD to testosterone in the prostate of black men. Higher tissue SHBG may activate the androgen receptor through cyclic adenosine monophosphate dependent pathways.