MORPHINE ABSTINENCE AND SEROTONIN SUPER-SENSITIVITY IN MAN - ANALOGIES WITH THE MECHANISM OF MIGRAINE
MORPHINE ABSTINENCE AND SEROTONIN SUPER-SENSITIVITY IN MAN - ANALOGIES WITH THE MECHANISM OF MIGRAINE
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DOI：
10.1007/bf00433050
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发表时间：
1979-01-01
影响因子：
3.4
通讯作者：
ANSELMI, B
中科院分区：
文献类型：
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作者：
SICUTERI, F;DELBIANCO, PL;ANSELMI, B
偏头痛发作时对5-羟色胺的超敏反应以前曾被观察到。由于发作归因于吗啡样因子的严重降低，因此在吗啡戒断期间预计会出现5-羟色胺超敏反应。在轻度（10-24 mg/天）和有限（3天）治疗后，在志愿者中诱导了轻微的吗啡戒断体征。为评价在体大鼠手背静脉平滑肌对5-羟色胺、多巴胺、去甲肾上腺素和酪胺的敏感性，在吗啡戒断前、戒断中和戒断后24 h，应用计算机静脉试验。吗啡戒断后，静脉对5-羟色胺和多巴胺的敏感性增加了10-20倍（但对去甲肾上腺素和酪胺的敏感性没有增加）。吗啡戒断时的静脉单胺超敏反应，类似于偏头痛发作时观察到的，可能是这两种情况下类似机制的间接证据。
Supersensitivity to serotonin during migraine attack was previously observed. Since the attack was attributed to a critical lowering of morphine-like factors, serotonin supersensitivity is expected during morphine abstinence. Slight signs of morphine abstinence were induced in volunteers after mild (10-24 mg/day) and limited (3 days) treatment. To evaluate the sensitivity to serotonin, dopamine, norepinephrine and tyramine in the smooth muscle of the hand dorsal vein, in vivo, the computerized venotest was applied before, during and 24 h after withdrawal of morphine. Venous sensitivity to serotonin and dopamine (but not to norepinephrine and tyramine) increased 10-20 fold after morphine withdrawal. Venous monoamine supersensitivity in morphine abstinence, similar to that observed during migraine attacks, could be indirect evidence of an analogous mechanism in both conditions.