Exposure to cement dust, related occupational groups and laryngeal cancer risk: Results of a population based case-control study
Exposure to cement dust, related occupational groups and laryngeal cancer risk: Results of a population based case-control study
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DOI：
10.1002/ijc.11658
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发表时间：
2004-03-01
影响因子：
6.4
通讯作者：
Becher, H
中科院分区：
文献类型：
--
作者：
Dietz, A;Ramroth, H;Becher, H
在德国莱茵-内卡地区进行了一项基于人群的病例对照研究，以评估喉癌发生的职业危险因素(“莱茵-内卡-喉癌研究”)。1998年5月至2000年12月，纳入257例喉癌患者(男性236例，女性21例)，年龄37-80岁，以及769例人群对照组(男性702例，女性67例)(按年龄和性别匹配的频率为1：3)。职业接触史以及其他危险因素(烟草、酒精)是通过使用详细的标准化问卷进行面对面访谈获得的。评估了完整的个人工作历史。工作条件的详细评估是通过特定工作问卷(JQ)获得的，调查对象是已知与潜在喉癌致癌物暴露相关的选定工作。按物质分列的总接触时数估计数是根据JQ计算的。已发表的职业卫生数据被用来推断特定工作任务的暴露强度的半定量分数。在对烟草和酒精摄入量进行调整后，在建筑和建筑工人的工作期间接触水泥的人的优势比(OR)可能显著增加。高暴露组工人的OR值为2.42(95%可信区间：1.14-5.15；p<；0.001)。吸烟是主要的混杂因素，调整烟草摄入量后，未调整的水泥OR为3.20，降至2.42。我们的结论是，有很好的证据表明，水泥粉尘暴露是烟草、酒精和石棉对喉癌的独立危险因素。本研究为该课题的进一步毒理学研究奠定了基础。(C)2003年Wiley-Liss，Inc.
A population-based case-control study was performed in the Rhein-Neckar region, Germany, to evaluate occupational risk factors for the development of laryngeal cancer ("Rhein-Neckar-Larynx Study"). Between May 1998 and December 2000, 257 patients (236 males, 21 females), aged 37-80, with histologically confirmed laryngeal cancer, as well as 769 population control persons (702 males, 67 females), were included (1:3 frequency matched by age and sex). History of occupational exposures, as well as other risk factors (tobacco, alcohol), was obtained with face-to-face interviews using a detailed standardized questionnaire. The complete individual work history was assessed. A detailed assessment of work conditions was obtained by job-specific questionnaires (JSQs) for selected jobs known to be associated with exposure to potential laryngeal carcinogens. Estimates for total exposure hours by substance were calculated based on JSQs. Published occupational hygiene data were used to infer semiquantitative scores of exposure intensity for specific job tasks. After adjustment for tobacco and alcohol intake, a significant elevated odds ratios (OR) could be demonstrated for persons that were exposed to cement during their work as building and construction workers. An OR of 2.42 was calculated for workers of the high exposed subgroup (95% confidence interval: 1.14-5.15; p < 0.001). Smoking was the main confounding factor because the unadjusted cement OR of 3.20 dropped down to 2.42 after adjustment for tobacco intake. We conclude that there is good evidence for cement dust exposure acting as a tobacco, alcohol and asbestos independent risk factor for laryngeal carcinoma. Our study gives a base for further toxicologic investigations on this topic. (C) 2003 Wiley-Liss, Inc.