Epigenetics of T cells regulated by Polycomb/Trithorax molecules.
Epigenetics of T cells regulated by Polycomb/Trithorax molecules.
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DOI：
10.1016/j.molmed.2015.03.001
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发表时间：
2015-05
影响因子：
13.6
通讯作者：
A. Onodera;T. Nakayama
中科院分区：
文献类型：
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作者：
A. Onodera;T. Nakayama
表观遗传学在遗传因素和环境因素之间架起了一座桥梁，可以在不改变基因组序列的情况下改变基因的转录结果。过敏和自身免疫性疾病是由这两种因素引起的，并且已经报道了T细胞中表观遗传标记的动态变化，T细胞是免疫介导疾病发病机制的关键参与者。技术的进步，包括基因敲除系统和高通量测序，大大提高了对T细胞寿命的理解，包括成熟，分化和记忆形成。在这篇综述中，我们专注于Polycomb和Trithorax蛋白，良好的表征表观遗传调节剂，并讨论了它们在T细胞分化和功能的表观遗传调节中的作用。
Epigenetics provides a bridge between genetic and environmental factors, and can change the transcriptional outcome of a gene without changing the genomic sequence. Allergies and autoimmune diseases are caused by both of these factors, and dynamic changes in epigenetic marks have been reported in T cells, which are key players in the pathogenesis of immune-mediated diseases. Advances in technology, including gene knockout systems and high-throughput sequencing, have significantly enhanced the understanding of the lifespan of T cells, including maturation, differentiation and memory formation. In this review, we focus on Polycomb and Trithorax proteins, well-characterized epigenetic modulators, and discuss their role in the epigenetic regulation of T cell differentiation and function.