Bladder cancer in crack testers applying azo dye-based sprays to metal bodies.
Bladder cancer in crack testers applying azo dye-based sprays to metal bodies.
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将偶氮染料喷雾剂应用于金属体的裂纹测试仪中的膀胱癌。
DOI：
10.1080/15287394.2012.675309
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Selinski,Silvia
中科院分区：
文献类型：
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作者：
Golka,Klaus;Kopps,Silke;Prager,Hans-Martin;Mende,Stephanv;Thiel,Ralf;Jungmann,Olaf;Zumbe,Jürgen;Bolt,HermannM;Blaszkewicz,Meinolf;Hengstler,JanG;Selinski,Silvia
由于偶氮染料中含有致癌芳香胺，可能会导致膀胱癌。对九例疑似职业性膀胱癌病例进行了检查，这些病例在金属相关工作中接触过不同的裂纹测试喷雾剂。记录详细的职业史，如果可能的话，确定 N-乙酰转移酶 2 (NAT2) 状态。首次接触裂纹测试喷雾的时间为 1957 年至 1986 年。首次接触的年龄为 14 至 33 岁。首次诊断膀胱癌的年龄从 35 岁到 64 岁不等。潜伏期在 17 至 45 年之间。报告的最长暴露时间为 29 年。六个基因分型病例中有四个是慢NAT2乙酰化者。裂纹测试喷雾的处理包括将含有红色染料的物质喷射到金属体上并用抹布洗掉喷雾。因此，工人通过皮肤接触和吸入而暴露于病毒。裂纹测试喷雾在洗掉红色测试喷雾化合物并施加额外的白色喷雾后使裂纹可见，该喷雾含有溶剂红 19（苏丹红 7B，N-乙基-1[[4-（苯基偶氮）苯基]偶氮]-2-萘胺）或对苯基偶氮苯胺-N-乙基-2-萘胺和对苯基偶氮苯胺-N-乙基-1-萘胺的混合物等染料。芳香胺2-萘胺被国际癌症研究机构和国家当局列为人类致癌物，自20世纪50年代中期以来在许多国家已被禁用。需要明确询问从事金属相关工作的膀胱癌患者是否使用裂纹测试喷雾剂。
Bladder cancer may be produced by azo dyes due to the presence of carcinogenic aromatic amines. Nine cases of suspected occupational bladder cancer that were exposed to different crack test sprays in metal-related jobs were examined. A detailed occupational history was taken and, if possible, theN-acetyltransferase 2 (NAT2) status was determined. The first exposure to crack test sprays ranged from 1957 to 1986. Age at first exposure was between 14 and 33 yr. Age at first diagnosis of bladder cancer varied from 35 to 64 yr. Latency periods were between 17 and 45 yr. The maximal reported exposure period was 29 yr. Four of six genotyped cases were slowNAT2acetylators. The handling of the crack test spray included spraying the red dye-containing matter on the metal body and washing off the spray with a rag. Thus, workers were exposed by dermal contact as well as by inhalation. The crack test spray, which makes the cracks visible after washing off the red testing spray compounds and applying an additional white spray, contained dyes such as solvent red 19 (Sudan red 7B,N-ethyl-1[[4-(phenylazo)phenyl]azo]-2-naphthylamine) or a mixture ofp-phenylazoaniline-N-ethyl-2-naphthylamine andp-phenylazoaniline-N-ethyl-1-naphthylamine. The aromatic amine 2-naphthylamine is classified as human carcinogen by IARC and the national authorities and has been banned in many countries since the mid 1950s. Bladder cancer patients with metal-related jobs need to be explicitly asked about the use of crack test sprays.