In Vitro Assessment of EmboGel and UltraGel Radiopaque Hydrogels for the Endovascular Treatment of Aneurysms
In Vitro Assessment of EmboGel and UltraGel Radiopaque Hydrogels for the Endovascular Treatment of Aneurysms
复制标题
DOI：
10.1016/j.jvir.2009.01.005
复制
发表时间：
2009-04-01
影响因子：
2.9
通讯作者：
Gailloud, Philippe H.
中科院分区：
文献类型：
--
作者：
Barnett, Brad P.;Hughes, Andrew H.;Gailloud, Philippe H.
目的：描述两种水凝胶栓塞材料，基于藻酸盐的 EmboGel 和基于聚乙二醇二丙烯酸酯的 UltraGel，并检查它们在腹主动脉瘤 (AAA) 内漏和囊状动脉瘤体外模型中作为栓塞剂的用途。 材料和方法：EmboGel 是碘海醇和藻酸盐的混合物，并用氯化钙溶液诱导聚合。 UltraGel 是 igracure、碘海醇和聚乙二醇二丙烯酸酯的混合物，在紫外 (UV) 光存在下聚合。两种情况均使用改良的微导管输送系统，以证明水凝胶在梭状和囊状动脉瘤模型中的用途。结果：初步体外结果表明，EmboGel 和 UltraGel 分别在梭状和囊状动脉瘤模型中提供有效的栓塞。由于 EmboGel 的快速聚合，该试剂以线状形式释放。当与 AAA 内漏模型中的支架结合使用时，这种形式能够有效地填充动脉瘤腔并阻断中央血流。相反，UltraGel 以液体形式输送，并在紫外光存在下缓慢聚合。囊状动脉瘤模型中的该系统能够在动脉瘤壁内形成固体铸件，再次显示出母血流完全闭塞。结论：初步结果表明，这两种新型水凝胶应用可能对治疗囊状和梭形动脉瘤有效。
PURPOSE: To describe two hydrogel embolic materials, the alginate-based EmboGel and the polyethylene glycol diacrylate-based UltraGel and examine their use as embolic agents in in vitro models of abdominal aortic aneurysm (AAA) endoleak and saccular aneurysms.MATERIALS AND METHODS: EmboGel is a mixture of iohexol and alginate, with a calcium chloride solution used to induce polymerization. UltraGel is a mixture of igracure, iohexol, and polyethylene glycol diacrylate and polymerizes in the presence of ultraviolet (UV) light. Modified microcatheter delivery systems were used in both cases to demonstrate use of the hydrogels in fusiform and saccular aneurysm models.RESULTS: Preliminary in vitro results suggest that EmboGel and UltraGel provide effective embolization in fusiform and saccular aneurysm models, respectively. Due to the rapid polymerization of EmboGel, the agent was delivered in a strand-like form. When used in conjunction with a stent in an AAA endoleak model, this form was able to effectively fill the aneurysmal cavity and occlude it from the central blood flow. UltraGel, conversely, was delivered as a liquid and slowly polymerized in the presence of UV light. This system in a saccular aneurysm model was able to form a solid cast inside the aneurysm wall, again showing complete occlusion from the parent flow.CONCLUSIONS: Preliminary results indicate these two novel hydrogel applications may prove effective for the treatment of saccular and fusiform aneurysms.