InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines.
InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines.
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DOI：
10.1021/ol401489x
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发表时间：
2013-07
期刊：
影响因子：
5.2
通讯作者：
Pingyuan Wang;Shan-shan Song;Z. Miao;Guangfu Yang;A. Zhang
中科院分区：
文献类型：
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作者：
Pingyuan Wang;Shan-shan Song;Z. Miao;Guangfu Yang;A. Zhang
报道了一种由1，2-环丙-3-吡喃酮与伯胺一锅法合成多羟基烷基取代吡咯的方法。用10%的InBr 3作为催化剂，芳基胺和烷基胺以及各种1，2-环丙-3-吡喃酮都具有良好的耐受性。该方法具有一锅法、反应条件温和、底物简单、底物范围广等优点。
An efficient one-pot synthesis of polyhydroxyalkyl-substituted pyrroles from 1,2-cyclopropa-3-pyranones with primary amines is reported. With 10% of InBr3 as the catalyst, both aryl- and alkylamines as well as various 1,2-cyclopropa-3-pyranones are well tolerated. This method is highly appealing because of its one-pot process, mild reaction conditions, substrate simplicity, and broad substrate scope.