Control of MMP-9 expression at the maternal-fetal interface
Control of MMP-9 expression at the maternal-fetal interface
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DOI：
10.1016/s0165-0378(01)00142-5
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发表时间：
2002-05-01
影响因子：
3.4
通讯作者：
Campana, A
中科院分区：
文献类型：
--
作者：
Bischof, P;Meisser, A;Campana, A
早孕胎盘细胞滋养层细胞(CTB)形成侵袭性CTB柱。这种侵袭行为是由于CTB分泌基质金属蛋白酶(MMPs)的能力，因为基质金属蛋白酶的组织抑制因子(TIMP)抑制了它们的侵袭。虽然CTB的行为类似于转移细胞，但在体内，它们只是短暂的侵袭(妊娠早期)，而且它们的侵袭通常仅限于子宫内膜和子宫肌层的近三分之一。滋养细胞侵袭的这种时空调节被认为是由滋养细胞因子以自分泌方式调节的，而由子宫因素以旁分泌方式调节的。已经研究了几种类型的调节剂：激素、细胞外基质糖蛋白和细胞因子或生长因子。这篇综述并不是对滋养层细胞分泌基质金属蛋白酶-9的潜在调节因素进行详尽的分类，而是旨在总结参与基质金属蛋白酶-9调节的最重要的信号通路。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Cytotrophoblastic cells (CTB) from first trimester placenta form columns of invasive CTB. This invasive behaviour is due to the ability of CTB to secrete matrix metalloproteinases (MMPs) since tissue inhibitor of MMP (TIMP) inhibits their invasiveness. Although CTB behave like metastatic cells, in vivo they are only transiently invasive (first trimester) and their invasion is normally limited only to the endometrium and to the proximal third of the myometrium. This temporal and spatial regulation of trophoblast invasion is believed to be mediated in an autocrine way by trophoblastic factors and in a paracrine way by uterine factors. Several types of regulators have been investigated: hormones, extra-cellular matrix glycoproteins and cytokines or growth factors. This review is not intended to be an exhaustive catalogue of potential regulators of trophoblastic MMP-9 secretion but is aimed at summarising the most important signalling pathways involved in MMP-9 regulation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.