Genetic Architecture of Tameness in a Rat Model of Animal Domestication
Genetic Architecture of Tameness in a Rat Model of Animal Domestication
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DOI：
10.1534/genetics.109.102186
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发表时间：
2009-06-01
期刊：
影响因子：
3.3
通讯作者：
Paabo, Svante
中科院分区：
文献类型：
--
作者：
Albert, Frank W.;Carlborg, Orjan;Paabo, Svante
家养动物的一个共同特征是温顺--即它们容忍并不怕人类的存在和处理。为了深入了解温顺和攻击性的遗传基础，我们研究了两个品系的大鼠(褐家鼠)的杂交，这些品系分别在>；60代中选择了更强的温顺和对人类更强的攻击性。我们测量了来自杂交种群的700只大鼠的45个特征，包括驯服和攻击性、焦虑相关特征、器官重量和血清成分水平。利用201个遗传标记，我们定位了两个显著的温顺数量性状基因座。这些基因座与肾上腺重量和焦虑相关性状的QTL重叠，是影响驯服的五个基因座上位网络的一部分。一个额外的QTL影响白煤的赋存。斑点，但对驯化没有显著影响。这里描述的基因座是寻找导致这些大鼠驯服的基因的重要起点，也可能是一般家畜的温顺基因。
A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coal. spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.