Functional estrogen receptorαimaging in endometrial carcinoma using 16α-[^<18> F] fluoro-17β-estradiol PET
Functional estrogen receptorαimaging in endometrial carcinoma using 16α-[^<18> F] fluoro-17β-estradiol PET
复制标题
使用16α-[^18F]氟17β-雌二醇PET对子宫内膜癌进行功能性雌激素受体α成像
DOI：
10.1007/s00259-010-1589-8
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Okazawa H.
中科院分区：
文献类型：
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作者：
Tsujikawa T;Yoshida Y;Kiyono Y;Kurokawa T;Kudo T;Fujibayashi Y;Kotsuji F;Okazawa H.
目的对子宫内膜癌患者术前进行正电子发射断层扫描（PET），探讨16α-[18F]氟-17β-雌二醇（FES）摄取与雌激素受体及其他相关免疫组织化学标志物表达的关系。方法19例子宫内膜样腺癌患者术前行FES和2-[18F]氟-2-脱氧-d -葡萄糖（FDG） PET检查。利用共配准后的图像计算每种示踪剂的标准化摄取值（SUV）和区域FDG与FES SUV的比值。比较两组患者术后分期、分化等级及雌激素受体亚型（ERα、ERβ）、孕激素受体B （PR-B）、Ki-67和葡萄糖转运蛋白1 （GLUT1）的免疫组化评分。结果fes摄取与ERα表达呈显著正相关。FDG / FES与ERα、PR-B表达呈显著负相关。FES摄取和FDG / FES比值与ERβ、Ki-67和GLUT1的表达无关。FDG摄取与任何免疫组织化学评分无关。PR-B评分与ERα评分呈显著正相关。高分化癌（1级）与中度或低分化癌（2-3级）相比，FES摄取显著增加，FDG / FES比值显著降低。晚期癌（≥IB期）与早期癌（IA期）的PET参数均无统计学差异。多变量分析结果表明，分化等级是与FES摄取和FDG / FES比值关系最密切的参数。结论fes PET联合FDG可用于无创评价子宫内膜癌ERα分布及ERα功能，反映子宫内膜癌分化程度。
PurposeTo investigate the correlation between uptake of 16α-[18F]fluoro-17β-oestradiol (FES) and expression of oestrogen receptors as well as other related immunohistochemistry markers, positron emission tomography (PET) was performed in patients with endometrial carcinoma before surgery.MethodsNineteen patients with endometrioid adenocarcinoma underwent preoperative PET studies with FES and 2-[18F]fluoro-2-deoxy-D-glucose (FDG). Standardized uptake values (SUVs) for each tracer and the regional FDG to FES SUV ratio were calculated using images after coregistration. PET values were compared with postoperative stage, differentiation grade and immunohistochemical scores including oestrogen receptor subtypes (ERα, ERβ), progesterone receptor B (PR-B), Ki-67 and glucose transporter 1 (GLUT1).ResultsFES uptake showed a significantly positive correlation with expression of ERα. The FDG to FES ratio showed a significantly negative correlation with expression of ERα and PR-B. The FES uptake and FDG to FES ratio did not correlate with expression of ERβ, Ki-67 or GLUT1. FDG uptake was not correlated with any of the immunohistochemical scores. The PR-B score was strongly correlated with the ERα score. Well-differentiated carcinoma (grade 1) showed a significantly higher FES uptake and significantly lower FDG to FES ratio than moderately or poorly differentiated carcinoma (grade 2–3). None of the PET parameters were significantly different between advanced-stage carcinoma (≥ stage IB) and early-stage carcinoma (IA) based on the Féderation International de Gynécologie et d’Obstétrique (FIGO) staging classification. Differentiation grade was the most closely correlated parameter to FES uptake and FDG to FES ratio by multivariate analyses.ConclusionFES PET combined with FDG would be useful for non-invasive evaluation of ERα distribution, as well as ERα function, which reflects differentiation grade in endometrial carcinoma.